Cargando…

The status of CDKN2A alpha (p16(INK4A)) and beta (p14(ARF)) transcripts in thyroid tumour progression

CDKN2A locus on chromosome 9p21 encodes two tumour suppressor proteins pl6(INK4A), which is a regulator of the retinoblastoma (RB) protein, and p14(ARF), which is involved in the ARF–Mdm2–p53 pathway. The aim of this study was to determine if CDKN2A gene products are implicated in differentiated thy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ferru, A, Fromont, G, Gibelin, H, Guilhot, J, Savagner, F, Tourani, J M, Kraimps, J L, Larsen, C J, Karayan-Tapon, L
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2006
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2360765/ https://www.ncbi.nlm.nih.gov/pubmed/17117177 http://dx.doi.org/10.1038/sj.bjc.6603479

Ejemplares similares

Prognostic value of increase in transcript levels of Tp73 ΔEx2-3 isoforms in low-grade glioma patients
por: Wager, M, et al.
Publicado: (2006)

Semaphorin, neuropilin and VEGF expression in glial tumours: SEMA3G, a prognostic marker?
por: Karayan-Tapon, L, et al.
Publicado: (2008)

Prognostic molecular markers with no impact on decision-making: the paradox of gliomas based on a prospective study
por: Wager, M, et al.
Publicado: (2008)

MDM2 is an important prognostic and predictive factor for platin–pemetrexed therapy in malignant pleural mesotheliomas and deregulation of P14/ARF (encoded by CDKN2A) seems to contribute to an MDM2-driven inactivation of P53
por: Walter, R F H, et al.
Publicado: (2015)

Epigenetic changes in the CDKN2A locus are associated with differential expression of P16INK4A and P14ARF in HPV-positive oropharyngeal squamous cell carcinoma
por: Schlecht, Nicolas F, et al.
Publicado: (2015)

The Senescence Markers p16INK4A, p14ARF/p19ARF, and p21 in Organ Development and Homeostasis
por: Wagner, Kay-Dietrich, et al.
Publicado: (2022)

Methylation status of p14ARF and p16INK4a as detected in pancreatic secretions
por: Klump, B, et al.
Publicado: (2003)

Different cellular p16(INK4a) localisation may signal different survival outcomes in head and neck cancer
por: Zhao, N, et al.
Publicado: (2012)

Differential p16/INK4A cyclin-dependent kinase inhibitor expression correlates with chemotherapy efficacy in a cohort of 88 malignant pleural mesothelioma patients
por: Jennings, C J, et al.
Publicado: (2015)

Frequency and prognostic significance of p16(INK4A) protein overexpression and transcriptionally active human papillomavirus infection in laryngeal squamous cell carcinoma
por: Young, R J, et al.
Publicado: (2015)

Aberrations of the p14(ARF) and p16(INK4a) Genes in Renal Cell Carcinomas
por: Kawada, Yoichi, et al.
Publicado: (2001)

Sporadic CDKN2 (MTS1/p16ink4) gene alterations in human ovarian tumours.
por: Schuyer, M., et al.
Publicado: (1996)

High Positive Correlations between ANRIL and p16-CDKN2A/p15-CDKN2B/p14-ARF Gene Cluster Overexpression in Multi-Tumor Types Suggest Deregulated Activation of an ANRIL–ARF Bidirectional Promoter
por: Drak Alsibai, Kinan, et al.
Publicado: (2019)

Emerging Roles for the INK4a/ARF (CDKN2A) Locus in Adipose Tissue: Implications for Obesity and Type 2 Diabetes
por: Kahoul, Yasmina, et al.
Publicado: (2020)

Human papillomavirus, p16(INK4A), and Ki-67 in relation to clinicopathological variables and survival in primary carcinoma of the vagina
por: Hellman, K, et al.
Publicado: (2014)

The prognostic value of CDKN2A hypermethylation in colorectal cancer: a meta-analysis
por: Xing, X, et al.
Publicado: (2013)

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis
por: Liu, Yan, et al.
Publicado: (2009)

Aberrant CDKN1A transcriptional response associates with abnormal sensitivity to radiation treatment
por: Badie, C, et al.
Publicado: (2008)

Independent prognostic significance of cell cycle regulator proteins p16(INK4a) and pRb in advanced-stage ovarian carcinoma including optimally debulked patients: a translational research subprotocol of a randomised study of the Arbeitsgemeinschaft Gynaekologische Onkologie Ovarian Cancer Study Group
por: Kommoss, S, et al.
Publicado: (2007)

p16(INK4A) and p14(ARF) Gene Promoter Hypermethylation as Prognostic Biomarker in Oral and Oropharyngeal Squamous Cell Carcinoma: A Review
por: Al-Kaabi, A., et al.
Publicado: (2014)

Implications of Genetic and Epigenetic Alterations of CDKN2A (p16(INK4a)) in Cancer
por: Zhao, Ran, et al.
Publicado: (2016)

Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf)
por: Chernova, Tatyana, et al.
Publicado: (2017)

Effect of Iodine Intake on p14ARF and p16INK4a Expression in Thyroid Papillary Carcinoma in Rats
por: Sun, Ruimei, et al.
Publicado: (2015)

Immortalization of mouse myogenic cells can occur without loss of p16(INK4a), p19(ARF), or p53 and is accelerated by inactivation of Bax
por: Nowak, Jonathan A, et al.
Publicado: (2004)

Multivariate analysis of oestrogen receptor alpha, pS2, metallothionein and CD24 expression in invasive breast cancers
por: Surowiak, P, et al.
Publicado: (2006)

Ratio of Expression of p16(INK4a) to p14(ARF) Correlates with the Progression of Non‐small Cell Lung Cancer
por: Moriyama, Satoru, et al.
Publicado: (2002)

Frequent deletion of the CDKN2A locus in chordoma: analysis of chromosomal imbalances using array comparative genomic hybridisation
por: Hallor, K H, et al.
Publicado: (2008)

Role of Ink4a/Arf Locus in Beta Cell Mass Expansion under Physiological and Pathological Conditions
por: Salas, Elisabet, et al.
Publicado: (2014)

The Cdkn2a gene product p19 alternative reading frame (p19ARF) is a critical regulator of IFNβ-mediated Lyme arthritis
por: Li, Jinze, et al.
Publicado: (2022)

New insights on the regulation of INK4/ARF locus expression
por: Gamell, Cristina, et al.
Publicado: (2017)

DNA methylation in the promoter region of the p16 (CDKN2/MTS-1/INK4A) gene in human breast tumours
por: Woodcock, D M, et al.
Publicado: (1999)

CDKN2A/p16INK4(a) expression is associated with vascular progeria in chronic kidney disease
por: Stenvinkel, Peter, et al.
Publicado: (2017)

Role of p14(ARF) and p15(INK4B) promoter methylation in patients with lung cancer: a systematic meta-analysis
por: Yang, Xinmei, et al.
Publicado: (2016)

Clinical significance of p16(INK4A) and p14(ARF) promoter methylation in renal cell carcinoma: a meta-analysis
por: Ren, Yu, et al.
Publicado: (2017)

Death-associated protein 3 is overexpressed in human thyroid oncocytic tumours
por: Jacques, C, et al.
Publicado: (2009)

Molecular Analysis of Tumor Suppressor Genes, Rb, p53,pl6INK4A, pl5INK4B and p14ARF in Natural Killer Cell Neoplasms
por: Sakajiri, Sakura, et al.
Publicado: (2001)

Frequency and clinical impact of CDKN2A/ARF/CDKN2B gene deletions as assessed by in-depth genetic analyses in adult T cell acute lymphoblastic leukemia
por: Genescà, E., et al.
Publicado: (2018)

The effects of fucodian on senescence are controlled by the p16(INK4a)-pRb and p14(Arf)-p53 pathways in hepatocellular carcinoma and hepatic cell lines
por: MIN, EUN-YOUNG, et al.
Publicado: (2014)

Individuals with presumably hereditary uveal melanoma do not harbour germline mutations in the coding regions of either the P16(INK4A), P14(ARF) or cdk4 genes
por: Soufir, N, et al.
Publicado: (2000)

Dominant role of CDKN2B/p15INK4B of 9p21.3 tumor suppressor hub in inhibition of cell-cycle and glycolysis
por: Xia, Yong, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_ln2kt0b48nshc0hbc2htpp0rpt