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Magnetic field exposure and long-term survival among children with leukaemia
We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2006
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361064/ https://www.ncbi.nlm.nih.gov/pubmed/16404370 http://dx.doi.org/10.1038/sj.bjc.6602916 |
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author | Foliart, D E Pollock, B H Mezei, G Iriye, R Silva, J M Ebi, K L Kheifets, L Link, M P Kavet, R |
author_facet | Foliart, D E Pollock, B H Mezei, G Iriye, R Silva, J M Ebi, K L Kheifets, L Link, M P Kavet, R |
author_sort | Foliart, D E |
collection | PubMed |
description | We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h MF measurements were obtained from 412 participants. A total of 386 children with ALL and 361 with B-precursor ALL were included in the analysis of event-free survival (time from diagnosis to first treatment failure, relapse, secondary malignancy, or death) and overall survival. After adjustment for risk group and socioeconomic status, the event-free survival hazard ratio (HR) for children with measurements ⩾0.3 μT was 1.9 (95% confidence interval (CI) 0.8, 4.9), compared to <0.1 μT. For survival, elevated HRs were found for children exposed to ⩾0.3 μT (multivariate HR=4.5, 95% CI 1.5–13.8) but based on only four deaths among 19 children. While risk was increased among children with exposures above 0.3 μT, the small numbers limited inferences for this finding. |
format | Text |
id | pubmed-2361064 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2006 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23610642009-09-10 Magnetic field exposure and long-term survival among children with leukaemia Foliart, D E Pollock, B H Mezei, G Iriye, R Silva, J M Ebi, K L Kheifets, L Link, M P Kavet, R Br J Cancer Epidemiology We examined the association between magnetic field (MF) exposure and survival among children with acute lymphoblastic leukaemia (ALL) treated at 51 Pediatric Oncology Group centres between 1996 and 2001. Of 1672 potentially eligible children under treatment, 482 (29%) participated and personal 24-h MF measurements were obtained from 412 participants. A total of 386 children with ALL and 361 with B-precursor ALL were included in the analysis of event-free survival (time from diagnosis to first treatment failure, relapse, secondary malignancy, or death) and overall survival. After adjustment for risk group and socioeconomic status, the event-free survival hazard ratio (HR) for children with measurements ⩾0.3 μT was 1.9 (95% confidence interval (CI) 0.8, 4.9), compared to <0.1 μT. For survival, elevated HRs were found for children exposed to ⩾0.3 μT (multivariate HR=4.5, 95% CI 1.5–13.8) but based on only four deaths among 19 children. While risk was increased among children with exposures above 0.3 μT, the small numbers limited inferences for this finding. Nature Publishing Group 2006-01-16 2006-01-10 /pmc/articles/PMC2361064/ /pubmed/16404370 http://dx.doi.org/10.1038/sj.bjc.6602916 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Epidemiology Foliart, D E Pollock, B H Mezei, G Iriye, R Silva, J M Ebi, K L Kheifets, L Link, M P Kavet, R Magnetic field exposure and long-term survival among children with leukaemia |
title | Magnetic field exposure and long-term survival among children with leukaemia |
title_full | Magnetic field exposure and long-term survival among children with leukaemia |
title_fullStr | Magnetic field exposure and long-term survival among children with leukaemia |
title_full_unstemmed | Magnetic field exposure and long-term survival among children with leukaemia |
title_short | Magnetic field exposure and long-term survival among children with leukaemia |
title_sort | magnetic field exposure and long-term survival among children with leukaemia |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361064/ https://www.ncbi.nlm.nih.gov/pubmed/16404370 http://dx.doi.org/10.1038/sj.bjc.6602916 |
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