Cargando…

A phase I and pharmacokinetic study of novel taxane BMS-188797 and cisplatin in patients with advanced solid tumours

This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(−2) DL), combined with cisplatin (standard dose 75 mg m(−2)). In 16 patients with advanced malignancies...

Descripción completa

Detalles Bibliográficos
Autores principales: du Bois, A, Jung, B, Loehr, A, Schaller-Kranz, T, Cohen, M, Frickhofen, N
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361071/
https://www.ncbi.nlm.nih.gov/pubmed/16333310
http://dx.doi.org/10.1038/sj.bjc.6602886
Descripción
Sumario:This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(−2) DL), combined with cisplatin (standard dose 75 mg m(−2)). In 16 patients with advanced malignancies treated, one patient experienced dose-limiting febrile neutropenia, sepsis and severe colitis at the 150 mg m(−2) DL; at the 110 mg m(−2) DL one episode of dose-limiting grade 3 diarrhoea/nausea occurred. Grade 3/4 haematological toxicities were leucopenia/neutropenia; grade 3 nonhaematological toxicities were neuropathy, nausea, diarrhoea and stomatits. Objective response was seen in four patients, with three complete remissions in ovarian and cervical cancer patients. Pharmacokinetics of BMS-188797 appeared linear through the 110 mg m(−2), but not through the 150 mg m(−2) DL. The mean±SD values for clearance, distribution volume at steady state and terminal half-life during cycle 1 were 317±60 ml min(−1) m(−2), 258±96 l m(−2) and 30.8±7.7 h, respectively. The maximum tolerated and recommended phase II dose for BMS-188797 was 110 mg m(−2) (1-h infusion, every 3 weeks) combined with cisplatin 75 mg m(−2).