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Birth outcome in women with breast cancer

We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with t...

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Autores principales: Langagergaard, V, Gislum, M, Skriver, M V, Nørgård, B, Lash, T L, Rothman, K J, Sørensen, H T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361078/
https://www.ncbi.nlm.nih.gov/pubmed/16306874
http://dx.doi.org/10.1038/sj.bjc.6602878
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author Langagergaard, V
Gislum, M
Skriver, M V
Nørgård, B
Lash, T L
Rothman, K J
Sørensen, H T
author_facet Langagergaard, V
Gislum, M
Skriver, M V
Nørgård, B
Lash, T L
Rothman, K J
Sørensen, H T
author_sort Langagergaard, V
collection PubMed
description We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8–17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0–2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3–6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients.
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spelling pubmed-23610782009-09-10 Birth outcome in women with breast cancer Langagergaard, V Gislum, M Skriver, M V Nørgård, B Lash, T L Rothman, K J Sørensen, H T Br J Cancer Epidemiology We investigated whether maternal breast cancer affects birth outcome in a nationwide cohort study of 695 births from 1973 to 2002 of women with breast cancer with respect to preterm birth, low birth weight at term, stillbirth and congenital abnormalities as well as mean birth weight, compared with the outcomes of 33 443 births from unaffected mothers. There was no excess risk of adverse birth outcome for the 216 newborns of women with breast cancer before pregnancy. Stratification by mother's treatment did not change the results. For 37 newborns of women diagnosed during pregnancy, the prevalence ratio (PR) of preterm birth was 8.1 (95% confidence interval (CI): 3.8–17). However, 10 of the 12 preterm deliveries among these women were elective early deliveries. Among 442 births of women diagnosed in the 2 years from time of delivery, the PR of preterm birth was 1.4 (95% CI: 1.0–2.0), and the PR of low birth weight at term for boys was 2.9 (95% CI: 1.3–6.3). Overall, our results are reassuring regarding the risks of adverse birth outcome for breast cancer patients. Nature Publishing Group 2006-01-16 2005-11-22 /pmc/articles/PMC2361078/ /pubmed/16306874 http://dx.doi.org/10.1038/sj.bjc.6602878 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Langagergaard, V
Gislum, M
Skriver, M V
Nørgård, B
Lash, T L
Rothman, K J
Sørensen, H T
Birth outcome in women with breast cancer
title Birth outcome in women with breast cancer
title_full Birth outcome in women with breast cancer
title_fullStr Birth outcome in women with breast cancer
title_full_unstemmed Birth outcome in women with breast cancer
title_short Birth outcome in women with breast cancer
title_sort birth outcome in women with breast cancer
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361078/
https://www.ncbi.nlm.nih.gov/pubmed/16306874
http://dx.doi.org/10.1038/sj.bjc.6602878
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