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Increased level of chromosomal damage after irradiation of lymphocytes from BRCA1 mutation carriers
Deleterious mutations in the BRCA1 gene predispose women to an increased risk of breast and ovarian cancer. Many functional studies have suggested that BRCA1 has a role in DNA damage repair and failure in the DNA damage response pathway often leads to the accumulation of chromosomal aberrations. Her...
Autores principales: | Kote-Jarai, Z, Salmon, A, Mengitsu, T, Copeland, M, Ardern-Jones, A, Locke, I, Shanley, S, Summersgill, B, Lu, Y-j, Shipley, J, Eeles, R |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2006
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361110/ https://www.ncbi.nlm.nih.gov/pubmed/16404418 http://dx.doi.org/10.1038/sj.bjc.6602912 |
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