Evaluating the role of human papillomaviruses in conjunctival neoplasia

Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putat...

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Autores principales: Tornesello, M L, Duraturo, M L, Waddell, K M, Biryahwaho, B, Downing, R, Balinandi, S, Lucas, S B, Buonaguro, L, Buonaguro, F M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361142/
https://www.ncbi.nlm.nih.gov/pubmed/16404433
http://dx.doi.org/10.1038/sj.bjc.6602921
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author Tornesello, M L
Duraturo, M L
Waddell, K M
Biryahwaho, B
Downing, R
Balinandi, S
Lucas, S B
Buonaguro, L
Buonaguro, F M
author_facet Tornesello, M L
Duraturo, M L
Waddell, K M
Biryahwaho, B
Downing, R
Balinandi, S
Lucas, S B
Buonaguro, L
Buonaguro, F M
author_sort Tornesello, M L
collection PubMed
description Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0–1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas.
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spelling pubmed-23611422009-09-10 Evaluating the role of human papillomaviruses in conjunctival neoplasia Tornesello, M L Duraturo, M L Waddell, K M Biryahwaho, B Downing, R Balinandi, S Lucas, S B Buonaguro, L Buonaguro, F M Br J Cancer Short Communication Mucosal, cutaneous and Epidermodysplasia verruciformis (EV)-related human papillomaviruses (HPVs) were searched by broad-spectrum PCR in 86 conjunctival neoplasia biopsies and 63 conjunctival non-neoplastic control tissue from Ugandan subjects. Seven different EV-related HPV types, including a putative new HPV, and two mucosal HPVs were detected in 25% (14 out of 56) of HIV-positive, in 10% (three out of 30) of HIV-negative conjunctival neoplasia samples, and rarely (0–1.6%) in control subjects. The absence of high-risk HPVs and the low detection frequency of EV-related HPV types in more advanced tumour stages (10%) raise doubts about their role in conjunctival carcinomas. Nature Publishing Group 2006-02-13 2006-01-10 /pmc/articles/PMC2361142/ /pubmed/16404433 http://dx.doi.org/10.1038/sj.bjc.6602921 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Tornesello, M L
Duraturo, M L
Waddell, K M
Biryahwaho, B
Downing, R
Balinandi, S
Lucas, S B
Buonaguro, L
Buonaguro, F M
Evaluating the role of human papillomaviruses in conjunctival neoplasia
title Evaluating the role of human papillomaviruses in conjunctival neoplasia
title_full Evaluating the role of human papillomaviruses in conjunctival neoplasia
title_fullStr Evaluating the role of human papillomaviruses in conjunctival neoplasia
title_full_unstemmed Evaluating the role of human papillomaviruses in conjunctival neoplasia
title_short Evaluating the role of human papillomaviruses in conjunctival neoplasia
title_sort evaluating the role of human papillomaviruses in conjunctival neoplasia
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361142/
https://www.ncbi.nlm.nih.gov/pubmed/16404433
http://dx.doi.org/10.1038/sj.bjc.6602921
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