Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma

We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumo...

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Autores principales: Muller, D, Millon, R, Théobald, S, Hussenet, T, Wasylyk, B, du Manoir, S, Abecassis, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361229/
https://www.ncbi.nlm.nih.gov/pubmed/16598186
http://dx.doi.org/10.1038/sj.bjc.6603036
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author Muller, D
Millon, R
Théobald, S
Hussenet, T
Wasylyk, B
du Manoir, S
Abecassis, J
author_facet Muller, D
Millon, R
Théobald, S
Hussenet, T
Wasylyk, B
du Manoir, S
Abecassis, J
author_sort Muller, D
collection PubMed
description We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing.
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spelling pubmed-23612292009-09-10 Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma Muller, D Millon, R Théobald, S Hussenet, T Wasylyk, B du Manoir, S Abecassis, J Br J Cancer Short Communication We evaluated the expression and amplification of cyclin L1 (CCNL1) gene, a potential oncogene localised in the commonly amplified 3q25–28 region, in human head and neck squamous cell carcinomas (HNSCCs). Overexpression was observed in 55 out of 96 cases (57%) and amplification in nine out of 35 tumours (26%) with no relationships to the clinico-pathological parameters. The Cyclin L1 antibody we developed labels nuclear speckles in tumour cells compatible with a role for CCNL1 in RNA splicing. Nature Publishing Group 2006-04-10 2006-04-04 /pmc/articles/PMC2361229/ /pubmed/16598186 http://dx.doi.org/10.1038/sj.bjc.6603036 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Muller, D
Millon, R
Théobald, S
Hussenet, T
Wasylyk, B
du Manoir, S
Abecassis, J
Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title_full Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title_fullStr Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title_full_unstemmed Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title_short Cyclin L1 (CCNL1) gene alterations in human head and neck squamous cell carcinoma
title_sort cyclin l1 (ccnl1) gene alterations in human head and neck squamous cell carcinoma
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361229/
https://www.ncbi.nlm.nih.gov/pubmed/16598186
http://dx.doi.org/10.1038/sj.bjc.6603036
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