Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review

This qualitative systematic review of the clinical methodology used in randomised, controlled trials of oral opioids (morphine, hydromorphone, oxycodone) for cancer pain underlines the difficulties of good pain research in palliative care. The current literature lacks placebo-controlled superiority...

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Detalles Bibliográficos
Autores principales: Bell, R F, Wisløff, T, Eccleston, C, Kalso, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361312/
https://www.ncbi.nlm.nih.gov/pubmed/16705312
http://dx.doi.org/10.1038/sj.bjc.6603162
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author Bell, R F
Wisløff, T
Eccleston, C
Kalso, E
author_facet Bell, R F
Wisløff, T
Eccleston, C
Kalso, E
author_sort Bell, R F
collection PubMed
description This qualitative systematic review of the clinical methodology used in randomised, controlled trials of oral opioids (morphine, hydromorphone, oxycodone) for cancer pain underlines the difficulties of good pain research in palliative care. The current literature lacks placebo-controlled superiority trials. Recommendations for future research are discussed.
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spelling pubmed-23613122009-09-10 Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review Bell, R F Wisløff, T Eccleston, C Kalso, E Br J Cancer Review This qualitative systematic review of the clinical methodology used in randomised, controlled trials of oral opioids (morphine, hydromorphone, oxycodone) for cancer pain underlines the difficulties of good pain research in palliative care. The current literature lacks placebo-controlled superiority trials. Recommendations for future research are discussed. Nature Publishing Group 2006-06-05 2006-05-16 /pmc/articles/PMC2361312/ /pubmed/16705312 http://dx.doi.org/10.1038/sj.bjc.6603162 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Bell, R F
Wisløff, T
Eccleston, C
Kalso, E
Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title_full Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title_fullStr Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title_full_unstemmed Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title_short Controlled clinical trials in cancer pain. How controlled should they be? A qualitative systematic review
title_sort controlled clinical trials in cancer pain. how controlled should they be? a qualitative systematic review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361312/
https://www.ncbi.nlm.nih.gov/pubmed/16705312
http://dx.doi.org/10.1038/sj.bjc.6603162
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AT ecclestonc controlledclinicaltrialsincancerpainhowcontrolledshouldtheybeaqualitativesystematicreview
AT kalsoe controlledclinicaltrialsincancerpainhowcontrolledshouldtheybeaqualitativesystematicreview

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