Mutations of the transcription factor PU.1 are not associated with acute lymphoblastic leukaemia

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The transcription factor PU.1 plays a crucial role during normal haematopoiesis in both myeloid cells and B-lymphocytes. Mice with a disruption in both alleles of the PU.1 locus were found to lack macrophages and B cells and had delayed appearance of neutrophils. In addition, critical decrease of PU...

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Detalles Bibliográficos
Autores principales: Mueller, B U, Pabst, T, Hauser, P, Gilliland, G, Neuberg, D, Tenen, D G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361337/
https://www.ncbi.nlm.nih.gov/pubmed/16735999
http://dx.doi.org/10.1038/sj.bjc.6603198

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