hTERT phosphorylation by PKC is essential for telomerase holoprotein integrity and enzyme activity in head neck cancer cells

Telomerase activity is suppressed in normal somatic tissues but is activated in most cancer cells. We have previously found that all six telomerase subunit proteins, including hTERT and hsp90 are needed for full enzyme activity. Telomerase activity has been reported to be upregulated by protein kina...

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Detalles Bibliográficos
Autores principales: Chang, J T, Lu, Y-C, Chen, Y-J, Tseng, C-P, Chen, Y-L, Fang, C-W, Cheng, A-J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361368/
https://www.ncbi.nlm.nih.gov/pubmed/16508638
http://dx.doi.org/10.1038/sj.bjc.6603008

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