MicroRNAs in cell proliferation, cell death, and tumorigenesis

MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal...

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Detalles Bibliográficos
Autores principales: Hwang, H-W, Mendell, J T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2006
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361377/
https://www.ncbi.nlm.nih.gov/pubmed/16495913
http://dx.doi.org/10.1038/sj.bjc.6603023
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author Hwang, H-W
Mendell, J T
author_facet Hwang, H-W
Mendell, J T
author_sort Hwang, H-W
collection PubMed
description MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors.
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spelling pubmed-23613772009-09-10 MicroRNAs in cell proliferation, cell death, and tumorigenesis Hwang, H-W Mendell, J T Br J Cancer Minireview MicroRNAs (miRNAs) are a recently discovered class of ∼18–24 nucleotide RNA molecules that negatively regulate target mRNAs. All studied multicellular eukaryotes utilise miRNAs to regulate basic cellular functions including proliferation, differentiation, and death. It is now apparent that abnormal miRNA expression is a common feature of human malignancies. In this review, we will discuss how miRNAs influence tumorigenesis by acting as oncogenes and tumour suppressors. Nature Publishing Group 2006-03-27 2006-02-21 /pmc/articles/PMC2361377/ /pubmed/16495913 http://dx.doi.org/10.1038/sj.bjc.6603023 Text en Copyright © 2006 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Hwang, H-W
Mendell, J T
MicroRNAs in cell proliferation, cell death, and tumorigenesis
title MicroRNAs in cell proliferation, cell death, and tumorigenesis
title_full MicroRNAs in cell proliferation, cell death, and tumorigenesis
title_fullStr MicroRNAs in cell proliferation, cell death, and tumorigenesis
title_full_unstemmed MicroRNAs in cell proliferation, cell death, and tumorigenesis
title_short MicroRNAs in cell proliferation, cell death, and tumorigenesis
title_sort micrornas in cell proliferation, cell death, and tumorigenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361377/
https://www.ncbi.nlm.nih.gov/pubmed/16495913
http://dx.doi.org/10.1038/sj.bjc.6603023
work_keys_str_mv AT hwanghw micrornasincellproliferationcelldeathandtumorigenesis
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