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New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer
The aim of this study was to verify through relative survival (an estimate of cancer-specific survival) the true prognostic factors of colorectal cancer. The study involved 506 patients who underwent locally radical resection. All the clinical, histological and laboratory parameters were prognostica...
Autores principales: | , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
2008
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361462/ https://www.ncbi.nlm.nih.gov/pubmed/18026187 http://dx.doi.org/10.1038/sj.bjc.6604114 |
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author | Gobbi, P G Valentino, F Berardi, E Tronconi, C Brugnatelli, S Luinetti, O Moratti, R Corazza, G R |
author_facet | Gobbi, P G Valentino, F Berardi, E Tronconi, C Brugnatelli, S Luinetti, O Moratti, R Corazza, G R |
author_sort | Gobbi, P G |
collection | PubMed |
description | The aim of this study was to verify through relative survival (an estimate of cancer-specific survival) the true prognostic factors of colorectal cancer. The study involved 506 patients who underwent locally radical resection. All the clinical, histological and laboratory parameters were prognostically analysed for both overall and relative survival. This latter was calculated from the expected survival of the general population with identical age, sex and calendar years of observation. Univariate and multivariate analyses were applied to the proportional hazards model. Liver metastases, age, lymph node involvement and depth of bowel wall involvement were independent prognosticators of both overall and relative survival, whereas carcinoembryonic antigen (CEA) was predictive only of relative survival. Increasing age was unfavourably related to overall survival, but mildly protective with regard to relative survival. Three out of the five prognostic factors identified are the cornerstones of the current staging systems, and were confirmed as adequate by the analysis of relative survival. The results regarding age explain the conflicting findings so far obtained from studies considering overall survival only and advise against the adoption of absolute age limits in therapeutic protocols. Moreover, the prechemotherapy CEA level showed a high clinical value. |
format | Text |
id | pubmed-2361462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23614622009-09-10 New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer Gobbi, P G Valentino, F Berardi, E Tronconi, C Brugnatelli, S Luinetti, O Moratti, R Corazza, G R Br J Cancer Clinical Study The aim of this study was to verify through relative survival (an estimate of cancer-specific survival) the true prognostic factors of colorectal cancer. The study involved 506 patients who underwent locally radical resection. All the clinical, histological and laboratory parameters were prognostically analysed for both overall and relative survival. This latter was calculated from the expected survival of the general population with identical age, sex and calendar years of observation. Univariate and multivariate analyses were applied to the proportional hazards model. Liver metastases, age, lymph node involvement and depth of bowel wall involvement were independent prognosticators of both overall and relative survival, whereas carcinoembryonic antigen (CEA) was predictive only of relative survival. Increasing age was unfavourably related to overall survival, but mildly protective with regard to relative survival. Three out of the five prognostic factors identified are the cornerstones of the current staging systems, and were confirmed as adequate by the analysis of relative survival. The results regarding age explain the conflicting findings so far obtained from studies considering overall survival only and advise against the adoption of absolute age limits in therapeutic protocols. Moreover, the prechemotherapy CEA level showed a high clinical value. Nature Publishing Group 2008-01-29 2007-11-20 /pmc/articles/PMC2361462/ /pubmed/18026187 http://dx.doi.org/10.1038/sj.bjc.6604114 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Clinical Study Gobbi, P G Valentino, F Berardi, E Tronconi, C Brugnatelli, S Luinetti, O Moratti, R Corazza, G R New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title | New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title_full | New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title_fullStr | New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title_full_unstemmed | New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title_short | New insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
title_sort | new insights into the role of age and carcinoembryonic antigen in the prognosis of colorectal cancer |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361462/ https://www.ncbi.nlm.nih.gov/pubmed/18026187 http://dx.doi.org/10.1038/sj.bjc.6604114 |
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