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No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype

To pursue a borderline increased risk of breast cancer for carriers of two integrin beta(3) (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case–control study of 1088 women with breast cancer and 4815 female controls. Leu33Pro heterozygotes, homozygotes and heterozygotes+ho...

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Autores principales: Bojesen, S E, Tybjærg-Hansen, A, Axelsson, C K, Nordestgaard, B G
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361476/
https://www.ncbi.nlm.nih.gov/pubmed/15970922
http://dx.doi.org/10.1038/sj.bjc.6602674
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author Bojesen, S E
Tybjærg-Hansen, A
Axelsson, C K
Nordestgaard, B G
author_facet Bojesen, S E
Tybjærg-Hansen, A
Axelsson, C K
Nordestgaard, B G
author_sort Bojesen, S E
collection PubMed
description To pursue a borderline increased risk of breast cancer for carriers of two integrin beta(3) (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case–control study of 1088 women with breast cancer and 4815 female controls. Leu33Pro heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers had odds ratios for breast cancer of 1.0 (95% confidence interval: 0.8–1.1), 0.8 (0.5–1.2) and 1.0 (0.8–1.1), respectively. After stratification for conventional risk factors, odds ratio for breast cancer in heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers were not increased above 1.0 in any of the 14 strata examined. This was also true after stratification for tumour histological subtype and cancer stage at the time of diagnosis.
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spelling pubmed-23614762009-09-10 No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype Bojesen, S E Tybjærg-Hansen, A Axelsson, C K Nordestgaard, B G Br J Cancer Epidemiology To pursue a borderline increased risk of breast cancer for carriers of two integrin beta(3) (ITGB3) 33Pro alleles found in a recent prospective study, we conducted a case–control study of 1088 women with breast cancer and 4815 female controls. Leu33Pro heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers had odds ratios for breast cancer of 1.0 (95% confidence interval: 0.8–1.1), 0.8 (0.5–1.2) and 1.0 (0.8–1.1), respectively. After stratification for conventional risk factors, odds ratio for breast cancer in heterozygotes, homozygotes and heterozygotes+homozygotes vs noncarriers were not increased above 1.0 in any of the 14 strata examined. This was also true after stratification for tumour histological subtype and cancer stage at the time of diagnosis. Nature Publishing Group 2005-07-11 2005-06-21 /pmc/articles/PMC2361476/ /pubmed/15970922 http://dx.doi.org/10.1038/sj.bjc.6602674 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Bojesen, S E
Tybjærg-Hansen, A
Axelsson, C K
Nordestgaard, B G
No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title_full No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title_fullStr No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title_full_unstemmed No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title_short No association of breast cancer risk with integrin beta(3) (ITGB3) Leu33Pro genotype
title_sort no association of breast cancer risk with integrin beta(3) (itgb3) leu33pro genotype
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361476/
https://www.ncbi.nlm.nih.gov/pubmed/15970922
http://dx.doi.org/10.1038/sj.bjc.6602674
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