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O(6)-(4-bromothenyl)guanine reverses temozolomide resistance in human breast tumour MCF-7 cells and xenografts

Tumour resistance to chemotherapy involving methylating agents such as DTIC (dacarbazine) and temozolomide is linked to expression of the DNA repair protein O(6)-alkylguanine-DNA alkyltransferase (MGMT). There is considerable interest in improving the efficacy of such O(6)-alkylating chemotherapy by...

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Detalles Bibliográficos
Autores principales:	Clemons, M, Kelly, J, Watson, A J, Howell, A, McElhinney, R S, McMurry, T B H, Margison, G P
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2005
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361498/ https://www.ncbi.nlm.nih.gov/pubmed/16278661 http://dx.doi.org/10.1038/sj.bjc.6602833

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