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Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D

Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In th...

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Autores principales: Porojnicu, A C, Robsahm, T E, Ree, A H, Moan, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361596/
https://www.ncbi.nlm.nih.gov/pubmed/16136030
http://dx.doi.org/10.1038/sj.bjc.6602722
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author Porojnicu, A C
Robsahm, T E
Ree, A H
Moan, J
author_facet Porojnicu, A C
Robsahm, T E
Ree, A H
Moan, J
author_sort Porojnicu, A C
collection PubMed
description Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we have investigated the effect of the season of diagnosis on the risk of death among Hodgkin's lymphoma patients diagnosed in Norway between 1964 and 2000. Risk estimates were calculated as relative risk (RR), with 95% confidence intervals (95% CI), using Cox regression model. Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with ≈20% lower case fatality for patients diagnosed during autumn vs winter diagnosis (RR=0.783, 95% CI,−0.62 to 0.99; P=0.041). Notably, the improved autumnal survival rate was higher than 60% (RR=0.364, 95% CI, −0.15 to 0.87; P=0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy.
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spelling pubmed-23615962009-09-10 Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D Porojnicu, A C Robsahm, T E Ree, A H Moan, J Br J Cancer Epidemiology Experimental studies show that vitamin D derivatives are potent anticarcinogenic factors. Epidemiological observations support this, and vitamin D sufficiency has been hypothesised to be an important risk-reducing factor in several forms of cancer. Vitamin D level exhibits seasonal variations. In the present work, we have investigated the effect of the season of diagnosis on the risk of death among Hodgkin's lymphoma patients diagnosed in Norway between 1964 and 2000. Risk estimates were calculated as relative risk (RR), with 95% confidence intervals (95% CI), using Cox regression model. Epidemiological data for this period indicate that season of diagnosis is a strong prognostic factor for Hodgkin's lymphoma, with ≈20% lower case fatality for patients diagnosed during autumn vs winter diagnosis (RR=0.783, 95% CI,−0.62 to 0.99; P=0.041). Notably, the improved autumnal survival rate was higher than 60% (RR=0.364, 95% CI, −0.15 to 0.87; P=0.025) for patients younger than 30 years. This finding may be related to higher endogenous levels of vitamin D in autumn, with a favourable influence on the conventional therapy. Nature Publishing Group 2005-09-05 2005-08-02 /pmc/articles/PMC2361596/ /pubmed/16136030 http://dx.doi.org/10.1038/sj.bjc.6602722 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Porojnicu, A C
Robsahm, T E
Ree, A H
Moan, J
Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title_full Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title_fullStr Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title_full_unstemmed Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title_short Season of diagnosis is a prognostic factor in Hodgkin's lymphoma: a possible role of sun-induced vitamin D
title_sort season of diagnosis is a prognostic factor in hodgkin's lymphoma: a possible role of sun-induced vitamin d
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361596/
https://www.ncbi.nlm.nih.gov/pubmed/16136030
http://dx.doi.org/10.1038/sj.bjc.6602722
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