Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instability

Aurora kinases are key regulators of chromosome segregation during mitosis. We have previously shown by microarray analysis of primary lung carcinomas and matched normal tissue that AURKB (22 out of 37) and AURKA (15 out of 37) transcripts are frequently over-represented in these tumours. We now con...

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Detalles Bibliográficos
Autores principales: Smith, S L, Bowers, N L, Betticher, D C, Gautschi, O, Ratschiller, D, Hoban, P R, Booton, R, Santibáñez-Koref, M F, Heighway, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361619/
https://www.ncbi.nlm.nih.gov/pubmed/16222316
http://dx.doi.org/10.1038/sj.bjc.6602779

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