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Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer

To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT–PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological...

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Autores principales: Sakakibara, T, Hibi, K, Koike, M, Fujiwara, M, Kodera, Y, Ito, K, Nakao, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361636/
https://www.ncbi.nlm.nih.gov/pubmed/16091756
http://dx.doi.org/10.1038/sj.bjc.6602743
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author Sakakibara, T
Hibi, K
Koike, M
Fujiwara, M
Kodera, Y
Ito, K
Nakao, A
author_facet Sakakibara, T
Hibi, K
Koike, M
Fujiwara, M
Kodera, Y
Ito, K
Nakao, A
author_sort Sakakibara, T
collection PubMed
description To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT–PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in CRC. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19±0.43) compared to negative ones (0.35±0.42) (P=0.0037) as well as in distant metastasis-positive CRCs (3.50±1.18) compared to negative ones (0.99±0.30). The PAI-1 expression score markedly increased with the tumour stage (P=0.0063; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P=0.0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC.
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spelling pubmed-23616362009-09-10 Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer Sakakibara, T Hibi, K Koike, M Fujiwara, M Kodera, Y Ito, K Nakao, A Br J Cancer Molecular Diagnostics To test the hypothesis that plasminogen activator inhibitor-1 (PAI-1) may serve as a candidate marker for the malignancy of colorectal cancer (CRC), we performed a quantitative RT–PCR for PAI-1 gene and evaluated the possible relationship between PAI-1 gene expression levels and clinicopathological findings in CRC. A significant increase in PAI-1 expression scores was observed in lymph node metastasis-positive CRCs (2.19±0.43) compared to negative ones (0.35±0.42) (P=0.0037) as well as in distant metastasis-positive CRCs (3.50±1.18) compared to negative ones (0.99±0.30). The PAI-1 expression score markedly increased with the tumour stage (P=0.0063; ANOVA test). Moreover, multivariate analysis revealed the PAI-1 expression score to be a strong and independent prognostic factor for CRC (P=0.0432). These results suggested that PAI-1 might serve as a new parameter for the prediction of prognoses in CRC. Nature Publishing Group 2005-10-03 2005-08-09 /pmc/articles/PMC2361636/ /pubmed/16091756 http://dx.doi.org/10.1038/sj.bjc.6602743 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Sakakibara, T
Hibi, K
Koike, M
Fujiwara, M
Kodera, Y
Ito, K
Nakao, A
Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title_full Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title_fullStr Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title_full_unstemmed Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title_short Plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
title_sort plasminogen activator inhibitor-1 as a potential marker for the malignancy of colorectal cancer
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361636/
https://www.ncbi.nlm.nih.gov/pubmed/16091756
http://dx.doi.org/10.1038/sj.bjc.6602743
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