Systematic review of the relationship between family history and lung cancer risk

We performed a systematic review of 28 case–control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case–control and cohort studies show a significantly increased lung cancer risk associated wi...

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Autores principales: Matakidou, A, Eisen, T, Houlston, R S
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361640/
https://www.ncbi.nlm.nih.gov/pubmed/16160696
http://dx.doi.org/10.1038/sj.bjc.6602769
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author Matakidou, A
Eisen, T
Houlston, R S
author_facet Matakidou, A
Eisen, T
Houlston, R S
author_sort Matakidou, A
collection PubMed
description We performed a systematic review of 28 case–control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case–control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed.
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spelling pubmed-23616402009-09-10 Systematic review of the relationship between family history and lung cancer risk Matakidou, A Eisen, T Houlston, R S Br J Cancer Epidemiology We performed a systematic review of 28 case–control, 17 cohort and seven twin studies of the relationship between family history and risk of lung cancer and a meta-analysis of risk estimates. Data from both case–control and cohort studies show a significantly increased lung cancer risk associated with having an affected relative. Risk appears to be greater in relatives of cases diagnosed at a young age and in those with multiple affected family members. Increased lung cancer risk was observed in association with an affected spouse and twin studies, while limited, favour shared environmental exposures. The limitations of the currently published epidemiological studies to infer genetic susceptibility are discussed. Nature Publishing Group 2005-10-03 2005-09-06 /pmc/articles/PMC2361640/ /pubmed/16160696 http://dx.doi.org/10.1038/sj.bjc.6602769 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Matakidou, A
Eisen, T
Houlston, R S
Systematic review of the relationship between family history and lung cancer risk
title Systematic review of the relationship between family history and lung cancer risk
title_full Systematic review of the relationship between family history and lung cancer risk
title_fullStr Systematic review of the relationship between family history and lung cancer risk
title_full_unstemmed Systematic review of the relationship between family history and lung cancer risk
title_short Systematic review of the relationship between family history and lung cancer risk
title_sort systematic review of the relationship between family history and lung cancer risk
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361640/
https://www.ncbi.nlm.nih.gov/pubmed/16160696
http://dx.doi.org/10.1038/sj.bjc.6602769
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