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Differential response to gefitinib of cells expressing normal EGFR and the mutant EGFRvIII
Epidermal growth factor receptor (EGFR) is frequently amplified and/or mutated in a number of human tumours and abnormal signalling from this receptor is believed to contribute to the malignant phenotype seen in these tumours. Gefitinib is a small molecule inhibitor that specifically binds and inhib...
| Autores principales: | , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361662/ https://www.ncbi.nlm.nih.gov/pubmed/16189524 http://dx.doi.org/10.1038/sj.bjc.6602793 |