Meta-analysis of cancer incidence in children born after assisted reproductive technologies

A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall S...

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Detalles Bibliográficos
Autores principales: Raimondi, S, Pedotti, P, Taioli, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361681/
https://www.ncbi.nlm.nih.gov/pubmed/16234814
http://dx.doi.org/10.1038/sj.bjc.6602838
Descripción
Sumario:A meta-analysis was performed on 11 cohort studies of Assisted Reproductive Technologies (ART) and subsequent childhood cancer, published up to February 2005, which reported comparable, nonoverlapping data, and then restricted to eight studies which presented a similar research design. The overall Standardised Incidence Ratio was 1.33 (95% CI 0.62–2.85), and 0.77 (95% CI 0.41–1.42) when the analysis was restricted to eight studies. No evidence of publication bias was observed for the overall analysis. The data are consistent with a lack of increase in risk of childhood cancer, though the amount of data on ART and cancer is still limited; larger multicentric studies as well as a pooled analysis on the available data are warranted.

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