DNA methylation-associated inactivation of TGFβ-related genes DRM/Gremlin, RUNX3, and HPP1 in human cancers

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The transforming growth factor β (TGFβ)-signalling pathway is deregulated in many cancers. We examined the role of gene silencing via aberrant methylation of DRM/Gremlin and HPP1, which inhibit TGFβ signalling, and RUNX3, which facilitates TGFβ-signalling, of all genes that are thought to be tumour...

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Detalles Bibliográficos
Autores principales: Suzuki, M, Shigematsu, H, Shames, D S, Sunaga, N, Takahashi, T, Shivapurkar, N, Iizasa, T, Frenkel, E P, Minna, J D, Fujisawa, T, Gazdar, A F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361683/
https://www.ncbi.nlm.nih.gov/pubmed/16234815
http://dx.doi.org/10.1038/sj.bjc.6602837
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