The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions

Mostrar otras versiones (1)

Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We...

Descripción completa

Detalles Bibliográficos
Autores principales: Antoniou, A C, Cunningham, A P, Peto, J, Evans, D G, Lalloo, F, Narod, S A, Risch, H A, Eyfjord, J E, Hopper, J L, Southey, M C, Olsson, H, Johannsson, O, Borg, A, Passini, B, Radice, P, Manoukian, S, Eccles, D M, Tang, N, Olah, E, Anton-Culver, H, Warner, E, Lubinski, J, Gronwald, J, Gorski, B, Tryggvadottir, L, Syrjakoski, K, Kallioniemi, O-P, Eerola, H, Nevanlinna, H, Pharoah, P D P, Easton, D F
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361716/
https://www.ncbi.nlm.nih.gov/pubmed/18349832
http://dx.doi.org/10.1038/sj.bjc.6604305
_version_ 1782153281997373440
author Antoniou, A C
Cunningham, A P
Peto, J
Evans, D G
Lalloo, F
Narod, S A
Risch, H A
Eyfjord, J E
Hopper, J L
Southey, M C
Olsson, H
Johannsson, O
Borg, A
Passini, B
Radice, P
Manoukian, S
Eccles, D M
Tang, N
Olah, E
Anton-Culver, H
Warner, E
Lubinski, J
Gronwald, J
Gorski, B
Tryggvadottir, L
Syrjakoski, K
Kallioniemi, O-P
Eerola, H
Nevanlinna, H
Pharoah, P D P
Easton, D F
author_facet Antoniou, A C
Cunningham, A P
Peto, J
Evans, D G
Lalloo, F
Narod, S A
Risch, H A
Eyfjord, J E
Hopper, J L
Southey, M C
Olsson, H
Johannsson, O
Borg, A
Passini, B
Radice, P
Manoukian, S
Eccles, D M
Tang, N
Olah, E
Anton-Culver, H
Warner, E
Lubinski, J
Gronwald, J
Gorski, B
Tryggvadottir, L
Syrjakoski, K
Kallioniemi, O-P
Eerola, H
Nevanlinna, H
Pharoah, P D P
Easton, D F
author_sort Antoniou, A C
collection PubMed
description Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920–1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html).
format Text
id pubmed-2361716
institution National Center for Biotechnology Information
language English
publishDate 2008
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23617162009-09-10 The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions Antoniou, A C Cunningham, A P Peto, J Evans, D G Lalloo, F Narod, S A Risch, H A Eyfjord, J E Hopper, J L Southey, M C Olsson, H Johannsson, O Borg, A Passini, B Radice, P Manoukian, S Eccles, D M Tang, N Olah, E Anton-Culver, H Warner, E Lubinski, J Gronwald, J Gorski, B Tryggvadottir, L Syrjakoski, K Kallioniemi, O-P Eerola, H Nevanlinna, H Pharoah, P D P Easton, D F Br J Cancer Genetics and Genomics Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and family data from BRCA1 and BRCA2 carriers identified by 22 population-based studies of breast or ovarian cancer. The combined data set includes 2785 families (301 BRCA1 positive and 236 BRCA2 positive). Incidences were smoothed using locally weighted regression techniques to avoid large variations between adjacent intervals. A birth cohort effect on the cancer risks was implemented, whereby each individual was assumed to develop cancer according to calendar period-specific incidences. The fitted model predicts that the average breast cancer risks in carriers increase in more recent birth cohorts. For example, the average cumulative breast cancer risk to age 70 years among BRCA1 carriers is 50% for women born in 1920–1929 and 58% among women born after 1950. The model was further extended to take into account the risks of male breast, prostate and pancreatic cancer, and to allow for the risk of multiple cancers. BOADICEA can be used to predict carrier probabilities and cancer risks to individuals with any family history, and has been implemented in a user-friendly Web-based program (http://www.srl.cam.ac.uk/genepi/boadicea/boadicea_home.html). Nature Publishing Group 2008-04-22 2008-03-18 /pmc/articles/PMC2361716/ /pubmed/18349832 http://dx.doi.org/10.1038/sj.bjc.6604305 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Antoniou, A C
Cunningham, A P
Peto, J
Evans, D G
Lalloo, F
Narod, S A
Risch, H A
Eyfjord, J E
Hopper, J L
Southey, M C
Olsson, H
Johannsson, O
Borg, A
Passini, B
Radice, P
Manoukian, S
Eccles, D M
Tang, N
Olah, E
Anton-Culver, H
Warner, E
Lubinski, J
Gronwald, J
Gorski, B
Tryggvadottir, L
Syrjakoski, K
Kallioniemi, O-P
Eerola, H
Nevanlinna, H
Pharoah, P D P
Easton, D F
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title_full The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title_fullStr The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title_full_unstemmed The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title_short The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions
title_sort boadicea model of genetic susceptibility to breast and ovarian cancers: updates and extensions
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361716/
https://www.ncbi.nlm.nih.gov/pubmed/18349832
http://dx.doi.org/10.1038/sj.bjc.6604305
work_keys_str_mv AT antoniouac theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT cunninghamap theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT petoj theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT evansdg theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT lalloof theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT narodsa theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT rischha theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eyfjordje theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT hopperjl theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT southeymc theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT olssonh theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT johannssono theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT borga theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT passinib theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT radicep theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT manoukians theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT ecclesdm theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT tangn theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT olahe theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT antonculverh theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT warnere theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT lubinskij theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT gronwaldj theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT gorskib theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT tryggvadottirl theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT syrjakoskik theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT kallioniemiop theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eerolah theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT nevanlinnah theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT pharoahpdp theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eastondf theboadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT antoniouac boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT cunninghamap boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT petoj boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT evansdg boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT lalloof boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT narodsa boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT rischha boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eyfjordje boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT hopperjl boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT southeymc boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT olssonh boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT johannssono boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT borga boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT passinib boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT radicep boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT manoukians boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT ecclesdm boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT tangn boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT olahe boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT antonculverh boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT warnere boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT lubinskij boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT gronwaldj boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT gorskib boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT tryggvadottirl boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT syrjakoskik boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT kallioniemiop boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eerolah boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT nevanlinnah boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT pharoahpdp boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions
AT eastondf boadiceamodelofgeneticsusceptibilitytobreastandovariancancersupdatesandextensions

Ejemplares similares