Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over...

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Detalles Bibliográficos
Autores principales: Szybka, M, Zawlik, I, Kulczycka, D, Golanska, E, Jesien, E, Kupnicka, D, Stawski, R, Piaskowski, S, Bieniek, E, Zakrzewska, M, Kordek, R, Liberski, P P, Rieske, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361718/
https://www.ncbi.nlm.nih.gov/pubmed/18349850
http://dx.doi.org/10.1038/sj.bjc.6604258
Descripción
Sumario:We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.

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