Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53

We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over...

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Autores principales: Szybka, M, Zawlik, I, Kulczycka, D, Golanska, E, Jesien, E, Kupnicka, D, Stawski, R, Piaskowski, S, Bieniek, E, Zakrzewska, M, Kordek, R, Liberski, P P, Rieske, P
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2008
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361718/
https://www.ncbi.nlm.nih.gov/pubmed/18349850
http://dx.doi.org/10.1038/sj.bjc.6604258
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author Szybka, M
Zawlik, I
Kulczycka, D
Golanska, E
Jesien, E
Kupnicka, D
Stawski, R
Piaskowski, S
Bieniek, E
Zakrzewska, M
Kordek, R
Liberski, P P
Rieske, P
author_facet Szybka, M
Zawlik, I
Kulczycka, D
Golanska, E
Jesien, E
Kupnicka, D
Stawski, R
Piaskowski, S
Bieniek, E
Zakrzewska, M
Kordek, R
Liberski, P P
Rieske, P
author_sort Szybka, M
collection PubMed
description We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene.
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spelling pubmed-23617182009-09-10 Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53 Szybka, M Zawlik, I Kulczycka, D Golanska, E Jesien, E Kupnicka, D Stawski, R Piaskowski, S Bieniek, E Zakrzewska, M Kordek, R Liberski, P P Rieske, P Br J Cancer Genetics and Genomics We screened 50 glioblastomas for P53 mutations. Five glioblastomas showed heterozygous mutations, while three were putatively heterozygous. Six of these eight glioblastomas showed elimination of wild-type P53 mRNA. These results strongly suggest that some sort of mechanism(s) favouring mutated over wild-type P53 mRNA exists in glioblastoma cells with heterozygous mutations of this gene. Nature Publishing Group 2008-04-22 2008-03-18 /pmc/articles/PMC2361718/ /pubmed/18349850 http://dx.doi.org/10.1038/sj.bjc.6604258 Text en Copyright © 2008 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Szybka, M
Zawlik, I
Kulczycka, D
Golanska, E
Jesien, E
Kupnicka, D
Stawski, R
Piaskowski, S
Bieniek, E
Zakrzewska, M
Kordek, R
Liberski, P P
Rieske, P
Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title_full Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title_fullStr Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title_full_unstemmed Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title_short Elimination of wild-type P53 mRNA in glioblastomas showing heterozygous mutations of P53
title_sort elimination of wild-type p53 mrna in glioblastomas showing heterozygous mutations of p53
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361718/
https://www.ncbi.nlm.nih.gov/pubmed/18349850
http://dx.doi.org/10.1038/sj.bjc.6604258
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