Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors

Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Thos...

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Autores principales: Weber, F, Fukino, K, Sawada, T, Williams, N, Sweet, K, Brena, R M, Plass, C, Caldes, T, Mutter, G L, Villalona-Calero, M A, Eng, C
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Genetics and Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361765/
https://www.ncbi.nlm.nih.gov/pubmed/15841079
http://dx.doi.org/10.1038/sj.bjc.6602557
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author Weber, F
Fukino, K
Sawada, T
Williams, N
Sweet, K
Brena, R M
Plass, C
Caldes, T
Mutter, G L
Villalona-Calero, M A
Eng, C
author_facet Weber, F
Fukino, K
Sawada, T
Williams, N
Sweet, K
Brena, R M
Plass, C
Caldes, T
Mutter, G L
Villalona-Calero, M A
Eng, C
author_sort Weber, F
collection PubMed
description Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy.
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spelling pubmed-23617652009-09-10 Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors Weber, F Fukino, K Sawada, T Williams, N Sweet, K Brena, R M Plass, C Caldes, T Mutter, G L Villalona-Calero, M A Eng, C Br J Cancer Genetics and Genomics Organ-specific differences in epidermal growth factor receptor (EGFR) mutational spectra and frequencies were found in lung cancer and sporadic and BRCA1/2-related breast cancers. Additionally, we found a high frequency of EGFR mutations in the tumour stroma of these invasive breast carcinomas. Those organ-specific mutational spectra and potential targets in the cancer-associated stroma might influence the efficacy of TKI therapy. Nature Publishing Group 2005-05-23 2005-04-19 /pmc/articles/PMC2361765/ /pubmed/15841079 http://dx.doi.org/10.1038/sj.bjc.6602557 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Genetics and Genomics
Weber, F
Fukino, K
Sawada, T
Williams, N
Sweet, K
Brena, R M
Plass, C
Caldes, T
Mutter, G L
Villalona-Calero, M A
Eng, C
Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title_full Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title_fullStr Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title_full_unstemmed Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title_short Variability in organ-specific EGFR mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
title_sort variability in organ-specific egfr mutational spectra in tumour epithelium and stroma may be the biological basis for differential responses to tyrosine kinase inhibitors
topic Genetics and Genomics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361765/
https://www.ncbi.nlm.nih.gov/pubmed/15841079
http://dx.doi.org/10.1038/sj.bjc.6602557
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