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HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation

Mutations in the Wnt signalling cascade are believed to cause aberrant proliferation of colorectal cells through T-cell factor-4 (TCF4) and its downstream growth-modulating factors. HOXB13 is exclusively expressed in prostate and colorectum. In prostate cancers, HOXB13 negatively regulates β-catenin...

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Detalles Bibliográficos
Autores principales:	Jung, C, Kim, R-S, Zhang, H, Lee, S-J, Sheng, H, Loehrer, P J, Gardner, T A, Jeng, M-H, Kao, C
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2005
Materias:	Molecular Diagnostics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361828/ https://www.ncbi.nlm.nih.gov/pubmed/15928669 http://dx.doi.org/10.1038/sj.bjc.6602631

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