Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay

Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of...

Descripción completa

Detalles Bibliográficos
Autores principales: Zlotnik, Y, Patya, M, Vanichkin, A, Novogrodsky, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361831/
https://www.ncbi.nlm.nih.gov/pubmed/15655545
http://dx.doi.org/10.1038/sj.bjc.6602324
_version_ 1782153310718918656
author Zlotnik, Y
Patya, M
Vanichkin, A
Novogrodsky, A
author_facet Zlotnik, Y
Patya, M
Vanichkin, A
Novogrodsky, A
author_sort Zlotnik, Y
collection PubMed
description Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine.
format Text
id pubmed-2361831
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23618312009-09-10 Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay Zlotnik, Y Patya, M Vanichkin, A Novogrodsky, A Br J Cancer Translational Therapeutics Intestinal injury that results from chemotherapy belongs to the major factors of dose-limitation in tumour therapy. The tyrphostins AG1714 and AG1801 reduce cisplatin and 5-FU-induced small intestinal mucosal damage, using a quantitative biochemical assay. The assay is based on the determination of the enzymatic activity of gamma-glutamyl transpeptidase, a marker of the brush border epithelium of the small intestine. Nature Publishing Group 2005-01-31 2005-01-18 /pmc/articles/PMC2361831/ /pubmed/15655545 http://dx.doi.org/10.1038/sj.bjc.6602324 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Translational Therapeutics
Zlotnik, Y
Patya, M
Vanichkin, A
Novogrodsky, A
Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title_full Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title_fullStr Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title_full_unstemmed Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title_short Tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
title_sort tyrphostins reduce chemotherapy-induced intestinal injury in mice: assessment by a biochemical assay
topic Translational Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361831/
https://www.ncbi.nlm.nih.gov/pubmed/15655545
http://dx.doi.org/10.1038/sj.bjc.6602324
work_keys_str_mv AT zlotniky tyrphostinsreducechemotherapyinducedintestinalinjuryinmiceassessmentbyabiochemicalassay
AT patyam tyrphostinsreducechemotherapyinducedintestinalinjuryinmiceassessmentbyabiochemicalassay
AT vanichkina tyrphostinsreducechemotherapyinducedintestinalinjuryinmiceassessmentbyabiochemicalassay
AT novogrodskya tyrphostinsreducechemotherapyinducedintestinalinjuryinmiceassessmentbyabiochemicalassay

Ejemplares similares