The prognostic significance of micrometastases in node-negative squamous cell carcinoma of the vulva

Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma (SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node-negative SCC from a population-based cohort of Grampian women. Median follow-up was 42 months after radical vu...

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Detalles Bibliográficos
Autores principales: Narayansingh, G V, Miller, I D, Sharma, M, Welch, C J, Sharp, L, Parkin, D E, Cruickshank, M E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361832/
https://www.ncbi.nlm.nih.gov/pubmed/15655537
http://dx.doi.org/10.1038/sj.bjc.6602343
Descripción
Sumario:Nodal involvement is one of the most significant prognostic factors in squamous cell carcinoma (SCC) of the vulva. We conducted a retrospective analysis of 31 women with histologically node-negative SCC from a population-based cohort of Grampian women. Median follow-up was 42 months after radical vulvectomy with groin node dissection. In total, 13 women (42%) were found to have micrometastases on immunohistochemistry. The risk of recurrence was almost 20-fold higher in those with micrometastases compared to those without (hazard ratio=19.6 (95% CI 2.3–171).

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