The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target

Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.

Detalles Bibliográficos
Autores principales: Kuroda, M, Kiyono, T, Oikawa, K, Yoshida, K, Mukai, K
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361835/
https://www.ncbi.nlm.nih.gov/pubmed/15655544
http://dx.doi.org/10.1038/sj.bjc.6602329
_version_ 1782153311761203200
author Kuroda, M
Kiyono, T
Oikawa, K
Yoshida, K
Mukai, K
author_facet Kuroda, M
Kiyono, T
Oikawa, K
Yoshida, K
Mukai, K
author_sort Kuroda, M
collection PubMed
description Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy.
format Text
id pubmed-2361835
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23618352009-09-10 The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target Kuroda, M Kiyono, T Oikawa, K Yoshida, K Mukai, K Br J Cancer Short Communication Here we show that human papillomavirus (HPV) E6 and E7 oncoproteins induce hWAPL expression. In addition, small interfering RNA (siRNA) of hWAPL suppressed the growth of tumours derived from SiHa cells in nude mice. Thus, hWAPL may be one of the effective targets of uterine cervical cancer therapy. Nature Publishing Group 2005-01-31 2005-01-11 /pmc/articles/PMC2361835/ /pubmed/15655544 http://dx.doi.org/10.1038/sj.bjc.6602329 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Kuroda, M
Kiyono, T
Oikawa, K
Yoshida, K
Mukai, K
The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title_full The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title_fullStr The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title_full_unstemmed The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title_short The human papillomavirus E6 and E7 inducible oncogene, hWAPL, exhibits potential as a therapeutic target
title_sort human papillomavirus e6 and e7 inducible oncogene, hwapl, exhibits potential as a therapeutic target
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361835/
https://www.ncbi.nlm.nih.gov/pubmed/15655544
http://dx.doi.org/10.1038/sj.bjc.6602329
work_keys_str_mv AT kurodam thehumanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT kiyonot thehumanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT oikawak thehumanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT yoshidak thehumanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT mukaik thehumanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT kurodam humanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT kiyonot humanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT oikawak humanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT yoshidak humanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget
AT mukaik humanpapillomaviruse6ande7inducibleoncogenehwaplexhibitspotentialasatherapeutictarget

Ejemplares similares