Cargando…

Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis

Sentinel lymph node biopsy (SLNB) has become a widely accepted standard procedure in the staging of patients with cutaneous melanoma and absence of clinical lymph node metastases, although there is no final proof that SLNB influences overall survival in these patients. This study investigated the ac...

Descripción completa

Detalles Bibliográficos
Autores principales: Roka, F, Kittler, H, Cauzig, P, Hoeller, C, Hinterhuber, G, Wolff, K, Pehamberger, H, Diem, E
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361872/
https://www.ncbi.nlm.nih.gov/pubmed/15700039
http://dx.doi.org/10.1038/sj.bjc.6602391
_version_ 1782153320882765824
author Roka, F
Kittler, H
Cauzig, P
Hoeller, C
Hinterhuber, G
Wolff, K
Pehamberger, H
Diem, E
author_facet Roka, F
Kittler, H
Cauzig, P
Hoeller, C
Hinterhuber, G
Wolff, K
Pehamberger, H
Diem, E
author_sort Roka, F
collection PubMed
description Sentinel lymph node biopsy (SLNB) has become a widely accepted standard procedure in the staging of patients with cutaneous melanoma and absence of clinical lymph node metastases, although there is no final proof that SLNB influences overall survival in these patients. This study investigated the accuracy of SLNB and the clinical outcome of patients after a mean follow-up of 22 months. Between 1998 and 2003, SLNB was performed in 309 consecutive patients. Patients with one or more positive sentinel lymph nodes (SLNs) were subjected to selective lymphadenectomy (SL). Survival analyses were performed using the Kaplan–Meier approach. A Cox proportional-hazard analysis was used for univariate and multivariate analysis to explore the effect of variables on survival. Sentinel lymph nodes were identified in 299 of 309 patients (success rate: 96.8%). Of these, 69 (23%) had a positive SLN. The false-negative rate was 9.2%. Recurrence of disease to the regional lymph node basin (3.0%) and to the locoregional skin (2.6%) was rare in SLN-negative patients in contrast to SLN-positive patients (7.2 and 17.4%, respectively). The 3-year overall survival was 93 and 83% for SLN-negative and SLN-positive patients, respectively. Upon multivariate analysis, SLN status (P<0.001), Breslow thickness (P<0.02) and ulceration (P<0.026) were all found to be independent prognostic factors with respect to disease-free survival, whereas Breslow thickness proved to be the only significant factor with respect to overall survival.
format Text
id pubmed-2361872
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23618722009-09-10 Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis Roka, F Kittler, H Cauzig, P Hoeller, C Hinterhuber, G Wolff, K Pehamberger, H Diem, E Br J Cancer Clinical Study Sentinel lymph node biopsy (SLNB) has become a widely accepted standard procedure in the staging of patients with cutaneous melanoma and absence of clinical lymph node metastases, although there is no final proof that SLNB influences overall survival in these patients. This study investigated the accuracy of SLNB and the clinical outcome of patients after a mean follow-up of 22 months. Between 1998 and 2003, SLNB was performed in 309 consecutive patients. Patients with one or more positive sentinel lymph nodes (SLNs) were subjected to selective lymphadenectomy (SL). Survival analyses were performed using the Kaplan–Meier approach. A Cox proportional-hazard analysis was used for univariate and multivariate analysis to explore the effect of variables on survival. Sentinel lymph nodes were identified in 299 of 309 patients (success rate: 96.8%). Of these, 69 (23%) had a positive SLN. The false-negative rate was 9.2%. Recurrence of disease to the regional lymph node basin (3.0%) and to the locoregional skin (2.6%) was rare in SLN-negative patients in contrast to SLN-positive patients (7.2 and 17.4%, respectively). The 3-year overall survival was 93 and 83% for SLN-negative and SLN-positive patients, respectively. Upon multivariate analysis, SLN status (P<0.001), Breslow thickness (P<0.02) and ulceration (P<0.026) were all found to be independent prognostic factors with respect to disease-free survival, whereas Breslow thickness proved to be the only significant factor with respect to overall survival. Nature Publishing Group 2005-02-28 2005-02-08 /pmc/articles/PMC2361872/ /pubmed/15700039 http://dx.doi.org/10.1038/sj.bjc.6602391 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Clinical Study
Roka, F
Kittler, H
Cauzig, P
Hoeller, C
Hinterhuber, G
Wolff, K
Pehamberger, H
Diem, E
Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title_full Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title_fullStr Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title_full_unstemmed Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title_short Sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
title_sort sentinel node status in melanoma patients is not predicitive for overall survival upon multivariate analysis
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361872/
https://www.ncbi.nlm.nih.gov/pubmed/15700039
http://dx.doi.org/10.1038/sj.bjc.6602391
work_keys_str_mv AT rokaf sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT kittlerh sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT cauzigp sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT hoellerc sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT hinterhuberg sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT wolffk sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT pehambergerh sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis
AT dieme sentinelnodestatusinmelanomapatientsisnotpredicitiveforoverallsurvivaluponmultivariateanalysis