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Increasing the intracellular availability of all-trans retinoic acid in neuroblastoma cells
Recent data indicate that isomerisation to all-trans retinoic acid (ATRA) is the key mechanism underlying the favourable clinical properties of 13-cis retinoic acid (13cisRA) in the treatment of neuroblastoma. Retinoic acid (RA) metabolism is thought to contribute to resistance, and strategies to mo...
Autores principales: | Armstrong, J L, Ruiz, M, Boddy, A V, Redfern, C P F, Pearson, A D J, Veal, G J |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361877/ https://www.ncbi.nlm.nih.gov/pubmed/15714209 http://dx.doi.org/10.1038/sj.bjc.6602398 |
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