Hypermethylation of the 5′ CpG island of the gene encoding the serine protease Testisin promotes its loss in testicular tumorigenesis

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The Testisin gene (PRSS21) encodes a glycosylphosphatidylinositol (GPI)-linked serine protease that exhibits testis tissue-specific expression. Loss of Testisin has been implicated in testicular tumorigenesis, but its role in testis biology and tumorigenesis is not known. Here we have investigated t...

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Detalles Bibliográficos
Autores principales: Manton, K J, Douglas, M L, Netzel-Arnett, S, Fitzpatrick, D R, Nicol, D L, Boyd, A W, Clements, J A, Antalis, T M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Molecular Diagnostics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361880/
https://www.ncbi.nlm.nih.gov/pubmed/15685234
http://dx.doi.org/10.1038/sj.bjc.6602373

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