Mutagenicity of comfrey (Symphytum Officinale) in rat liver

Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic...

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Autores principales: Mei, N, Guo, L, Fu, P P, Heflich, R H, Chen, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361893/
https://www.ncbi.nlm.nih.gov/pubmed/15726100
http://dx.doi.org/10.1038/sj.bjc.6602420
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author Mei, N
Guo, L
Fu, P P
Heflich, R H
Chen, T
author_facet Mei, N
Guo, L
Fu, P P
Heflich, R H
Chen, T
author_sort Mei, N
collection PubMed
description Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumorigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant.
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spelling pubmed-23618932009-09-10 Mutagenicity of comfrey (Symphytum Officinale) in rat liver Mei, N Guo, L Fu, P P Heflich, R H Chen, T Br J Cancer Short Communication Comfrey is a rat liver toxin and carcinogen that has been used as a vegetable and herbal remedy by humans. In order to evaluate the mechanisms underlying its carcinogenicity, we examined the mutagenicity of comfrey in the transgenic Big Blue rat model. Our results indicate that comfrey is mutagenic in rat liver and the types of mutations induced by comfrey suggest that its tumorigenicity results from the genotoxicity of pyrrolizidine alkaloids in the plant. Nature Publishing Group 2005-03-14 2005-02-22 /pmc/articles/PMC2361893/ /pubmed/15726100 http://dx.doi.org/10.1038/sj.bjc.6602420 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Mei, N
Guo, L
Fu, P P
Heflich, R H
Chen, T
Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title_full Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title_fullStr Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title_full_unstemmed Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title_short Mutagenicity of comfrey (Symphytum Officinale) in rat liver
title_sort mutagenicity of comfrey (symphytum officinale) in rat liver
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361893/
https://www.ncbi.nlm.nih.gov/pubmed/15726100
http://dx.doi.org/10.1038/sj.bjc.6602420
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