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Aberrant DNA methylation associated with silencing BNIP3 gene expression in haematopoietic tumours

Hypoxia is a key factor contributing to the progression of human neoplasias and to the development of resistance to chemotherapy. BNIP3 is a proapoptotic member of the Bcl-2 protein family involved in hypoxia-induced cell death. We evaluated the expression and methylation status of BNIP3 gene to bet...

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Detalles Bibliográficos
Autores principales:	Murai, M, Toyota, M, Satoh, A, Suzuki, H, Akino, K, Mita, H, Sasaki, Y, Ishida, T, Shen, L, Garcia-Manero, G, Issa, J-P J, Hinoda, Y, Tokino, T, Imai, K
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2005
Materias:	Genetics and Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361956/ https://www.ncbi.nlm.nih.gov/pubmed/15756280 http://dx.doi.org/10.1038/sj.bjc.6602422

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