The role of dendritic cell precursors in tumour vasculogenesis

In this review, we discuss the recent identification in vivo of a population of CD11c(+) cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, c...

Descripción completa

Detalles Bibliográficos
Autores principales: Coukos, G, Benencia, F, Buckanovich, R J, Conejo-Garcia, J R
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361965/
https://www.ncbi.nlm.nih.gov/pubmed/15785750
http://dx.doi.org/10.1038/sj.bjc.6602476
_version_ 1782153345317732352
author Coukos, G
Benencia, F
Buckanovich, R J
Conejo-Garcia, J R
author_facet Coukos, G
Benencia, F
Buckanovich, R J
Conejo-Garcia, J R
author_sort Coukos, G
collection PubMed
description In this review, we discuss the recent identification in vivo of a population of CD11c(+) cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into functional blood vessels or act as antigen-presenting cells. The identification of dendritic cell precursors as bipotent cells has important implications for the physiopathology and therapy of tumours. VLCs emerge as a novel therapeutic target against tumour vascularisation.
format Text
id pubmed-2361965
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23619652009-09-10 The role of dendritic cell precursors in tumour vasculogenesis Coukos, G Benencia, F Buckanovich, R J Conejo-Garcia, J R Br J Cancer Minireview In this review, we discuss the recent identification in vivo of a population of CD11c(+) cells exhibiting simultaneous expression of both endothelial and dendritic cell markers, termed vascular leukocytes (VLCs). VLCs are highly represented in human ovarian carcinomas and, depending on the milieu, can assemble into functional blood vessels or act as antigen-presenting cells. The identification of dendritic cell precursors as bipotent cells has important implications for the physiopathology and therapy of tumours. VLCs emerge as a novel therapeutic target against tumour vascularisation. Nature Publishing Group 2005-04-11 2005-03-22 /pmc/articles/PMC2361965/ /pubmed/15785750 http://dx.doi.org/10.1038/sj.bjc.6602476 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Minireview
Coukos, G
Benencia, F
Buckanovich, R J
Conejo-Garcia, J R
The role of dendritic cell precursors in tumour vasculogenesis
title The role of dendritic cell precursors in tumour vasculogenesis
title_full The role of dendritic cell precursors in tumour vasculogenesis
title_fullStr The role of dendritic cell precursors in tumour vasculogenesis
title_full_unstemmed The role of dendritic cell precursors in tumour vasculogenesis
title_short The role of dendritic cell precursors in tumour vasculogenesis
title_sort role of dendritic cell precursors in tumour vasculogenesis
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361965/
https://www.ncbi.nlm.nih.gov/pubmed/15785750
http://dx.doi.org/10.1038/sj.bjc.6602476
work_keys_str_mv AT coukosg theroleofdendriticcellprecursorsintumourvasculogenesis
AT benenciaf theroleofdendriticcellprecursorsintumourvasculogenesis
AT buckanovichrj theroleofdendriticcellprecursorsintumourvasculogenesis
AT conejogarciajr theroleofdendriticcellprecursorsintumourvasculogenesis
AT coukosg roleofdendriticcellprecursorsintumourvasculogenesis
AT benenciaf roleofdendriticcellprecursorsintumourvasculogenesis
AT buckanovichrj roleofdendriticcellprecursorsintumourvasculogenesis
AT conejogarciajr roleofdendriticcellprecursorsintumourvasculogenesis

Ejemplares similares