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Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells

Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying prolifer...

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Autores principales: Hofsli, E, Thommesen, L, Yadetie, F, Langaas, M, Kusnierczyk, W, Falkmer, U, Sandvik, A K, Laegreid, A
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361991/
https://www.ncbi.nlm.nih.gov/pubmed/15846300
http://dx.doi.org/10.1038/sj.bjc.6602535
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author Hofsli, E
Thommesen, L
Yadetie, F
Langaas, M
Kusnierczyk, W
Falkmer, U
Sandvik, A K
Laegreid, A
author_facet Hofsli, E
Thommesen, L
Yadetie, F
Langaas, M
Kusnierczyk, W
Falkmer, U
Sandvik, A K
Laegreid, A
author_sort Hofsli, E
collection PubMed
description Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in neuroendocrine (NE) gastrointestinal (GI) tumours, we investigated gene expression in human carcinoid BON cells after exposure to gastrin, hepatocyte growth factor (HGF), pituitary adenylate cyclase-activating polypeptide or epidermal growth factor. We particularly focused on gastrin- and HGF-induced gene expression, and identified 95 gastrin- and 101 HGF-responsive genes. The majority of these genes are known mediators of processes central in tumour biology, and a number of them have been associated with poor prognosis and metastasis in cancer patients. Furthermore, we identified 12 genes that were regulated by all four factors, indicating that they may be universally regulated during NE GI tumour cell proliferation. Our findings provide useful hypotheses for further studies aimed to search for new therapeutic targets as well as tumour markers in NE GI tumours.
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spelling pubmed-23619912009-09-10 Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells Hofsli, E Thommesen, L Yadetie, F Langaas, M Kusnierczyk, W Falkmer, U Sandvik, A K Laegreid, A Br J Cancer Molecular Diagnostics Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in neuroendocrine (NE) gastrointestinal (GI) tumours, we investigated gene expression in human carcinoid BON cells after exposure to gastrin, hepatocyte growth factor (HGF), pituitary adenylate cyclase-activating polypeptide or epidermal growth factor. We particularly focused on gastrin- and HGF-induced gene expression, and identified 95 gastrin- and 101 HGF-responsive genes. The majority of these genes are known mediators of processes central in tumour biology, and a number of them have been associated with poor prognosis and metastasis in cancer patients. Furthermore, we identified 12 genes that were regulated by all four factors, indicating that they may be universally regulated during NE GI tumour cell proliferation. Our findings provide useful hypotheses for further studies aimed to search for new therapeutic targets as well as tumour markers in NE GI tumours. Nature Publishing Group 2005-04-25 2005-04-20 /pmc/articles/PMC2361991/ /pubmed/15846300 http://dx.doi.org/10.1038/sj.bjc.6602535 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Molecular Diagnostics
Hofsli, E
Thommesen, L
Yadetie, F
Langaas, M
Kusnierczyk, W
Falkmer, U
Sandvik, A K
Laegreid, A
Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title_full Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title_fullStr Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title_full_unstemmed Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title_short Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
title_sort identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells
topic Molecular Diagnostics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361991/
https://www.ncbi.nlm.nih.gov/pubmed/15846300
http://dx.doi.org/10.1038/sj.bjc.6602535
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