HGS-ETR1, a fully human TRAIL-receptor 1 monoclonal antibody, induces cell death in multiple tumour types in vitro and in vivo

Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in a variety of tumour cells through activation of TRAIL-R1 and TRAIL-R2 death signalling receptors. Here, we describe the characterisation and activity of HGS-ETR1, the first fully human, agonistic TRAIL-R1 mAb that...

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Detalles Bibliográficos
Autores principales: Pukac, L, Kanakaraj, P, Humphreys, R, Alderson, R, Bloom, M, Sung, C, Riccobene, T, Johnson, R, Fiscella, M, Mahoney, A, Carrell, J, Boyd, E, Yao, X T, Zhang, L, Zhong, L, von Kerczek, A, Shepard, L, Vaughan, T, Edwards, B, Dobson, C, Salcedo, T, Albert, V
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2361994/
https://www.ncbi.nlm.nih.gov/pubmed/15846298
http://dx.doi.org/10.1038/sj.bjc.6602487

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