Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening

We prospectively evaluated the 5-year predictive values of adding high-risk human papillomavirus (hrHPV) testing to cytology for the detection of ⩾cervical intraepithelial neoplasia (CIN)3 lesions in a population-based cohort of 2810 women. At baseline, nine (0.3%) women had prevalent lesions ⩾CIN3,...

Descripción completa

Detalles Bibliográficos
Autores principales: Bulkmans, N W J, Rozendaal, L, Voorhorst, F J, Snijders, P J F, Meijer, C J L M
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Epidemiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362030/
https://www.ncbi.nlm.nih.gov/pubmed/15827553
http://dx.doi.org/10.1038/sj.bjc.6602541
_version_ 1782153361586388992
author Bulkmans, N W J
Rozendaal, L
Voorhorst, F J
Snijders, P J F
Meijer, C J L M
author_facet Bulkmans, N W J
Rozendaal, L
Voorhorst, F J
Snijders, P J F
Meijer, C J L M
author_sort Bulkmans, N W J
collection PubMed
description We prospectively evaluated the 5-year predictive values of adding high-risk human papillomavirus (hrHPV) testing to cytology for the detection of ⩾cervical intraepithelial neoplasia (CIN)3 lesions in a population-based cohort of 2810 women. At baseline, nine (0.3%) women had prevalent lesions ⩾CIN3, all being hrHPV positive. After 5 years of follow-up, four (6.5%) of the 62 hrHPV-positive women with normal cytology developed lesions ⩾CIN3, vs only one (0.05%) of the 2175 hrHPV-negative women with normal cytology. High-risk human papillomavirus testing or combined screening revealed a much higher sensitivity, at the cost of a small decrease in specificity, and a higher negative predictive value for the detection of lesions ⩾CIN3 till the next screening round (5 years) than cytology alone.
format Text
id pubmed-2362030
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23620302009-09-10 Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening Bulkmans, N W J Rozendaal, L Voorhorst, F J Snijders, P J F Meijer, C J L M Br J Cancer Epidemiology We prospectively evaluated the 5-year predictive values of adding high-risk human papillomavirus (hrHPV) testing to cytology for the detection of ⩾cervical intraepithelial neoplasia (CIN)3 lesions in a population-based cohort of 2810 women. At baseline, nine (0.3%) women had prevalent lesions ⩾CIN3, all being hrHPV positive. After 5 years of follow-up, four (6.5%) of the 62 hrHPV-positive women with normal cytology developed lesions ⩾CIN3, vs only one (0.05%) of the 2175 hrHPV-negative women with normal cytology. High-risk human papillomavirus testing or combined screening revealed a much higher sensitivity, at the cost of a small decrease in specificity, and a higher negative predictive value for the detection of lesions ⩾CIN3 till the next screening round (5 years) than cytology alone. Nature Publishing Group 2005-05-09 2005-04-12 /pmc/articles/PMC2362030/ /pubmed/15827553 http://dx.doi.org/10.1038/sj.bjc.6602541 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Epidemiology
Bulkmans, N W J
Rozendaal, L
Voorhorst, F J
Snijders, P J F
Meijer, C J L M
Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title_full Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title_fullStr Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title_full_unstemmed Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title_short Long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
title_sort long-term protective effect of high-risk human papillomavirus testing in population-based cervical screening
topic Epidemiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362030/
https://www.ncbi.nlm.nih.gov/pubmed/15827553
http://dx.doi.org/10.1038/sj.bjc.6602541
work_keys_str_mv AT bulkmansnwj longtermprotectiveeffectofhighriskhumanpapillomavirustestinginpopulationbasedcervicalscreening
AT rozendaall longtermprotectiveeffectofhighriskhumanpapillomavirustestinginpopulationbasedcervicalscreening
AT voorhorstfj longtermprotectiveeffectofhighriskhumanpapillomavirustestinginpopulationbasedcervicalscreening
AT snijderspjf longtermprotectiveeffectofhighriskhumanpapillomavirustestinginpopulationbasedcervicalscreening
AT meijercjlm longtermprotectiveeffectofhighriskhumanpapillomavirustestinginpopulationbasedcervicalscreening

Ejemplares similares