Cargando…
Preclinical relevance of dosing time for the therapeutic index of gemcitabine–cisplatin
The relevance of gemcitabine timing for chronotherapeutic optimisation was investigated. Healthy mice received multiple doses of gemcitabine (120, 160 or 200 mg kg(−1) injection (inj)(−1)) at one of six circadian times (3, 7, 11, 15, 19 or 23 h after light onset – HALO) on days 1, 4, 7 and 10 or a s...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2005
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362038/ https://www.ncbi.nlm.nih.gov/pubmed/15841076 http://dx.doi.org/10.1038/sj.bjc.6602564 |