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Pharmacokinetics and metabolism of ifosfamide in relation to DNA damage assessed by the COMET assay in children with cancer

The degree of damage to DNA following ifosfamide (IFO) treatment may be linked to the therapeutic efficacy. The pharmacokinetics and metabolism of IFO were studied in 19 paediatric patients, mostly with rhabdomyosarcoma or Ewings sarcoma. Ifosfamide was dosed either as a continuous infusion or as fr...

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Detalles Bibliográficos
Autores principales:	Willits, I, Price, L, Parry, A, Tilby, M J, Ford, D, Cholerton, S, Pearson, A D J, Boddy, A V
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2005
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362048/ https://www.ncbi.nlm.nih.gov/pubmed/15827549 http://dx.doi.org/10.1038/sj.bjc.6602554

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