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Phase I and pharmacokinetic study of the novel chemoprotector BNP7787 in combination with cisplatin and attempt to eliminate the hydration schedule

BNP7787 (disodium 2,2′-dithio-bis-ethane sulphonate; Tavocept™) is a novel agent developed to protect against cisplatin (cis-diammine-dichloroplatinum(II))-associated chronic toxicities. In this study, we determined the recommended dose of BNP7787 when preceding a fixed dose of cisplatin, the pharma...

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Detalles Bibliográficos
Autores principales:	Boven, E, Westerman, M, van Groeningen, C J, Verschraagen, M, Ruijter, R, Zegers, I, van der Vijgh, W J F, Giaccone, G
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2005
Materias:	Clinical Study
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362054/ https://www.ncbi.nlm.nih.gov/pubmed/15841080 http://dx.doi.org/10.1038/sj.bjc.6602553

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