Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis

A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4–16) – however, only two percent (95% CI: 0–5) was attributable to cure from salvage re-op...

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Autores principales: Renehan, A G, Egger, M, Saunders, M P, O'Dwyer, S T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 2005
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362076/
https://www.ncbi.nlm.nih.gov/pubmed/15685236
http://dx.doi.org/10.1038/sj.bjc.6602369
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author Renehan, A G
Egger, M
Saunders, M P
O'Dwyer, S T
author_facet Renehan, A G
Egger, M
Saunders, M P
O'Dwyer, S T
author_sort Renehan, A G
collection PubMed
description A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4–16) – however, only two percent (95% CI: 0–5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions.
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spelling pubmed-23620762009-09-10 Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis Renehan, A G Egger, M Saunders, M P O'Dwyer, S T Br J Cancer Short Communication A meta-analysis of six randomised trials demonstrated that intensive followup in colorectal cancer was associated with an absolute reduction in all-cause 5-year mortality of 10% (95% confidence interval (CI): 4–16) – however, only two percent (95% CI: 0–5) was attributable to cure from salvage re-operations. We postulate that other factors, such as increased psychological well-being and/or altered lifestyle, and/or improved treatment of coincidental disease may contribute to the remaining lives saved, and form important future research questions. Nature Publishing Group 2005-02-14 2005-02-01 /pmc/articles/PMC2362076/ /pubmed/15685236 http://dx.doi.org/10.1038/sj.bjc.6602369 Text en Copyright © 2005 Cancer Research UK https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Short Communication
Renehan, A G
Egger, M
Saunders, M P
O'Dwyer, S T
Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title_full Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title_fullStr Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title_full_unstemmed Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title_short Mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
title_sort mechanisms of improved survival from intensive followup in colorectal cancer: a hypothesis
topic Short Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362076/
https://www.ncbi.nlm.nih.gov/pubmed/15685236
http://dx.doi.org/10.1038/sj.bjc.6602369
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