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Carboxypeptidase G(2) rescue in patients with methotrexate intoxication and renal failure
The methotrexate (MTX) rescue agent carboxypeptidase G(2) (CPDG(2)) rapidly hydrolyses MTX to the inactive metabolite DAMPA (4-[[2,4-diamino-6-(pteridinyl)methyl]-methylamino]-benzoic acid) and glutamate in patients with MTX-induced renal failure and delayed MTX excretion. DAMPA is thought to be an...
| Autores principales: | , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
2005
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362096/ https://www.ncbi.nlm.nih.gov/pubmed/15668713 http://dx.doi.org/10.1038/sj.bjc.6602337 |