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Alcohol consumption and breast cancer oestrogen and progesterone receptor status
We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and firs...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362214/ https://www.ncbi.nlm.nih.gov/pubmed/10098777 http://dx.doi.org/10.1038/sj.bjc.6690210 |
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author | Enger, S M Ross, R K Paganini-Hill, A Longnecker, M P Bernstein, L |
author_facet | Enger, S M Ross, R K Paganini-Hill, A Longnecker, M P Bernstein, L |
author_sort | Enger, S M |
collection | PubMed |
description | We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23622142009-09-10 Alcohol consumption and breast cancer oestrogen and progesterone receptor status Enger, S M Ross, R K Paganini-Hill, A Longnecker, M P Bernstein, L Br J Cancer Regular Article We examined the role of alcohol on the risk of breast cancer by the joint oestrogen receptor (ER) and progesterone receptor (PR) status of the tumour using data from two case-control studies conducted in Los Angeles County, USA. Eligible premenopausal patients were 733 women aged ≤ 40 years and first diagnosed from 1 July 1983 to 1 January 1989. Eligible postmenopausal patients were 1169 women aged 55–64 years and first diagnosed from 1 March 1987 to 31 December 89. Patients were identified by the University of Southern California Cancer Surveillance Program. Neighbourhood controls were individually matched to patients by parity (premenopausal patients) and birth date (± 3 years). ER and PR status were obtained from medical records for 424 premenopausal and 760 postmenopausal patients. The analyses included 714 premenopausal and 1091 postmenopausal control subjects. Alcohol use was generally not associated with premenopausal risk of breast cancer, regardless of hormone-receptor status. Among the postmenopausal women, those who consumed, on average, ≥ 27 g of alcohol/d experienced an odds ratio (OR) of 1.76 [95% confidence interval (CI) 1.14–2.71] for ER-positive/PR-positive breast cancer relative to women who reported no alcohol consumption. Alcohol use was less clearly associated with risk of other receptor types among postmenopausal women. These data suggest that alcohol may preferentially increase risk of ER-positive/PR-positive breast cancer in postmenopausal women. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362214/ /pubmed/10098777 http://dx.doi.org/10.1038/sj.bjc.6690210 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Enger, S M Ross, R K Paganini-Hill, A Longnecker, M P Bernstein, L Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title | Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title_full | Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title_fullStr | Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title_full_unstemmed | Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title_short | Alcohol consumption and breast cancer oestrogen and progesterone receptor status |
title_sort | alcohol consumption and breast cancer oestrogen and progesterone receptor status |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362214/ https://www.ncbi.nlm.nih.gov/pubmed/10098777 http://dx.doi.org/10.1038/sj.bjc.6690210 |
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