A high incidence of vertebral fracture in women with breast cancer

Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general p...

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Autores principales: Kanis, J A, McCloskey, E V, Powles, T, Paterson, A H G, Ashley, S, Spector, T
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362233/
https://www.ncbi.nlm.nih.gov/pubmed/10098755
http://dx.doi.org/10.1038/sj.bjc.6690188
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author Kanis, J A
McCloskey, E V
Powles, T
Paterson, A H G
Ashley, S
Spector, T
author_facet Kanis, J A
McCloskey, E V
Powles, T
Paterson, A H G
Ashley, S
Spector, T
author_sort Kanis, J A
collection PubMed
description Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general population. The incidence of vertebral fracture, however, was nearly five times greater than normal in women from the time of first diagnosis [odds ratio (OR), 4.7; 95% confidence interval (95% CI), 2.3–9.9], and 20-fold higher in women with soft-tissue metastases without evidence of skeletal metastases (OR, 22.7; 95% CI, 9.1–57.1). We conclude that vertebral fracture risk is markedly increased in women with breast cancer. © 1999 Cancer Research Campaign
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spelling pubmed-23622332009-09-10 A high incidence of vertebral fracture in women with breast cancer Kanis, J A McCloskey, E V Powles, T Paterson, A H G Ashley, S Spector, T Br J Cancer Regular Article Because treatment for breast cancer may adversely affect skeletal metabolism, we investigated vertebral fracture risk in women with non-metastatic breast cancer. The prevalence of vertebral fracture was similar in women at the time of first diagnosis to that in an age-matched sample of the general population. The incidence of vertebral fracture, however, was nearly five times greater than normal in women from the time of first diagnosis [odds ratio (OR), 4.7; 95% confidence interval (95% CI), 2.3–9.9], and 20-fold higher in women with soft-tissue metastases without evidence of skeletal metastases (OR, 22.7; 95% CI, 9.1–57.1). We conclude that vertebral fracture risk is markedly increased in women with breast cancer. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362233/ /pubmed/10098755 http://dx.doi.org/10.1038/sj.bjc.6690188 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Kanis, J A
McCloskey, E V
Powles, T
Paterson, A H G
Ashley, S
Spector, T
A high incidence of vertebral fracture in women with breast cancer
title A high incidence of vertebral fracture in women with breast cancer
title_full A high incidence of vertebral fracture in women with breast cancer
title_fullStr A high incidence of vertebral fracture in women with breast cancer
title_full_unstemmed A high incidence of vertebral fracture in women with breast cancer
title_short A high incidence of vertebral fracture in women with breast cancer
title_sort high incidence of vertebral fracture in women with breast cancer
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362233/
https://www.ncbi.nlm.nih.gov/pubmed/10098755
http://dx.doi.org/10.1038/sj.bjc.6690188
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