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Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate
Hyaluronan (HA), an extracellular high-molecular-mass polysaccharide, is supposed to be involved in the growth and progression of malignant tumours. We studied the cellular expression of HA in 215 operated stage I–IV gastric cancer patients using a specific biotinylated probe. Most (93%) of the tumo...
Autores principales: | , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362238/ https://www.ncbi.nlm.nih.gov/pubmed/10098747 http://dx.doi.org/10.1038/sj.bjc.6690180 |
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author | Setälä, L P Tammi, M I Tammi, R H Eskelinen, M J Lipponen, P K Ågren, U M Parkkinen, J Alhava, E M Kosma, V-M |
author_facet | Setälä, L P Tammi, M I Tammi, R H Eskelinen, M J Lipponen, P K Ågren, U M Parkkinen, J Alhava, E M Kosma, V-M |
author_sort | Setälä, L P |
collection | PubMed |
description | Hyaluronan (HA), an extracellular high-molecular-mass polysaccharide, is supposed to be involved in the growth and progression of malignant tumours. We studied the cellular expression of HA in 215 operated stage I–IV gastric cancer patients using a specific biotinylated probe. Most (93%) of the tumours showed HA staining in their parenchyma, whereas the stroma inside and around the tumour was stained in every case. When HA expression was compared with the clinical and histological features of the tumours, a strong staining intensity in the tumour parenchyma was found to be associated with deep tumour invasion (pT3 or 4) and with mixed type of Laurén. A high proportion of HA-positive cells of all neoplastic cells was significantly associated with deep tumour invasion, nodal metastasis, positive lymphatic invasion, poor differentiation grade, as well as with inferior prognosis in univariate survival analysis. However, in multivariate analysis, only pT, pN, and vascular and lymphatic invasion emerged as independent predictors of survival in gastric cancer. The results indicate that ectopic HA expression is a frequent feature of gastric adenocarcinoma, and is associated with tumour progression and poor survival rate. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362238 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23622382009-09-10 Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate Setälä, L P Tammi, M I Tammi, R H Eskelinen, M J Lipponen, P K Ågren, U M Parkkinen, J Alhava, E M Kosma, V-M Br J Cancer Regular Article Hyaluronan (HA), an extracellular high-molecular-mass polysaccharide, is supposed to be involved in the growth and progression of malignant tumours. We studied the cellular expression of HA in 215 operated stage I–IV gastric cancer patients using a specific biotinylated probe. Most (93%) of the tumours showed HA staining in their parenchyma, whereas the stroma inside and around the tumour was stained in every case. When HA expression was compared with the clinical and histological features of the tumours, a strong staining intensity in the tumour parenchyma was found to be associated with deep tumour invasion (pT3 or 4) and with mixed type of Laurén. A high proportion of HA-positive cells of all neoplastic cells was significantly associated with deep tumour invasion, nodal metastasis, positive lymphatic invasion, poor differentiation grade, as well as with inferior prognosis in univariate survival analysis. However, in multivariate analysis, only pT, pN, and vascular and lymphatic invasion emerged as independent predictors of survival in gastric cancer. The results indicate that ectopic HA expression is a frequent feature of gastric adenocarcinoma, and is associated with tumour progression and poor survival rate. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362238/ /pubmed/10098747 http://dx.doi.org/10.1038/sj.bjc.6690180 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Setälä, L P Tammi, M I Tammi, R H Eskelinen, M J Lipponen, P K Ågren, U M Parkkinen, J Alhava, E M Kosma, V-M Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title | Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title_full | Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title_fullStr | Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title_full_unstemmed | Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title_short | Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
title_sort | hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362238/ https://www.ncbi.nlm.nih.gov/pubmed/10098747 http://dx.doi.org/10.1038/sj.bjc.6690180 |
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