Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients

We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) mutation in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185...

Descripción completa

Detalles Bibliográficos
Autores principales: Díez, O, Osorio, A, Robledo, M, Barroso, A, Domènech, M, Cortés, J, Albertos, J, Sanz, J, Brunet, J, SanRoḿn, J M, Alonso, M C, Baiget, M, Benítez, J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362239/
https://www.ncbi.nlm.nih.gov/pubmed/10098775
http://dx.doi.org/10.1038/sj.bjc.6690208
_version_ 1782153408349732864
author Díez, O
Osorio, A
Robledo, M
Barroso, A
Domènech, M
Cortés, J
Albertos, J
Sanz, J
Brunet, J
SanRoḿn, J M
Alonso, M C
Baiget, M
Benítez, J
author_facet Díez, O
Osorio, A
Robledo, M
Barroso, A
Domènech, M
Cortés, J
Albertos, J
Sanz, J
Brunet, J
SanRoḿn, J M
Alonso, M C
Baiget, M
Benítez, J
author_sort Díez, O
collection PubMed
description We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) mutation in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185delAG in both Sephardic and Ashkenazi populations. © 1999 Cancer Research Campaign
format Text
id pubmed-2362239
institution National Center for Biotechnology Information
language English
publishDate 1999
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-23622392009-09-10 Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients Díez, O Osorio, A Robledo, M Barroso, A Domènech, M Cortés, J Albertos, J Sanz, J Brunet, J SanRoḿn, J M Alonso, M C Baiget, M Benítez, J Br J Cancer Regular Article We screened the 185delAG and 5382insC (BRCA1) and the 6174delT (BRCA2) mutation in 298 Spanish women with breast cancer. Two women (one with Sephardic ancestors) presented the 185delAG mutation and the same haplotype reported in Ashkenazim with this mutation. This suggests a common origin of the 185delAG in both Sephardic and Ashkenazi populations. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362239/ /pubmed/10098775 http://dx.doi.org/10.1038/sj.bjc.6690208 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Díez, O
Osorio, A
Robledo, M
Barroso, A
Domènech, M
Cortés, J
Albertos, J
Sanz, J
Brunet, J
SanRoḿn, J M
Alonso, M C
Baiget, M
Benítez, J
Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title_full Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title_fullStr Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title_full_unstemmed Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title_short Prevalence of BRCA1 and BRCA2 Jewish mutations in Spanish breast cancer patients
title_sort prevalence of brca1 and brca2 jewish mutations in spanish breast cancer patients
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362239/
https://www.ncbi.nlm.nih.gov/pubmed/10098775
http://dx.doi.org/10.1038/sj.bjc.6690208
work_keys_str_mv AT diezo prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT osorioa prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT robledom prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT barrosoa prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT domenechm prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT cortesj prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT albertosj prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT sanzj prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT brunetj prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT sanromnjm prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT alonsomc prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT baigetm prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients
AT benitezj prevalenceofbrca1andbrca2jewishmutationsinspanishbreastcancerpatients

Ejemplares similares