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Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role?
In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimen...
Autores principales: | , , , |
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1999
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362241/ https://www.ncbi.nlm.nih.gov/pubmed/10098770 http://dx.doi.org/10.1038/sj.bjc.6690203 |
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author | Gillespie, A M Siddiqui, N Coleman, R E Hancock, B W |
author_facet | Gillespie, A M Siddiqui, N Coleman, R E Hancock, B W |
author_sort | Gillespie, A M |
collection | PubMed |
description | In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prophylactic chemotherapy for cerebral micrometastatic disease in persistent gestational trophoblastic disease is unclear. We have analysed the outcome of 69 patients with lung metastases who elsewhere might have received prophylactic intrathecal chemotherapy. Of the 69 patients, 67 received intravenous chemotherapy only. The other two patients had cerebral metastases at presentation. One patient who received only intravenous chemotherapy subsequently developed a cerebral metastasis, but this patient's initial treatment was compromised by non-compliance. This experience supports our current policy of not treating patients with pulmonary metastases, without clinical evidence of central nervous system (CNS) involvement, with prophylactic intrathecal therapy. © 1999 Cancer Research Campaign |
format | Text |
id | pubmed-2362241 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1999 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-23622412009-09-10 Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? Gillespie, A M Siddiqui, N Coleman, R E Hancock, B W Br J Cancer Regular Article In the UK there are standardized surveillance procedures for gestational trophoblastic disease. However, there are differences in practice between the two treatment centres in terms of definition of persistent gestational trophoblastic disease, prognostic risk assessment and chemotherapeutic regimens. The role of prophylactic chemotherapy for cerebral micrometastatic disease in persistent gestational trophoblastic disease is unclear. We have analysed the outcome of 69 patients with lung metastases who elsewhere might have received prophylactic intrathecal chemotherapy. Of the 69 patients, 67 received intravenous chemotherapy only. The other two patients had cerebral metastases at presentation. One patient who received only intravenous chemotherapy subsequently developed a cerebral metastasis, but this patient's initial treatment was compromised by non-compliance. This experience supports our current policy of not treating patients with pulmonary metastases, without clinical evidence of central nervous system (CNS) involvement, with prophylactic intrathecal therapy. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362241/ /pubmed/10098770 http://dx.doi.org/10.1038/sj.bjc.6690203 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Regular Article Gillespie, A M Siddiqui, N Coleman, R E Hancock, B W Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title | Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title_full | Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title_fullStr | Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title_full_unstemmed | Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title_short | Gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
title_sort | gestational trophoblastic disease: does central nervous system chemoprophylaxis have a role? |
topic | Regular Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362241/ https://www.ncbi.nlm.nih.gov/pubmed/10098770 http://dx.doi.org/10.1038/sj.bjc.6690203 |
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