Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3

The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded...

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Autores principales: Cleton-Jansen, A-M, Moerland, E W, Pronk, J C, van Berkel, C G M, Apostolou, S, Crawford, J, Savoia, A, Auerbach, A D, Mathew, C G, Callen, D F, Cornelisse, C J
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1999
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362253/
https://www.ncbi.nlm.nih.gov/pubmed/10098735
http://dx.doi.org/10.1038/sj.bjc.6690168
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author Cleton-Jansen, A-M
Moerland, E W
Pronk, J C
van Berkel, C G M
Apostolou, S
Crawford, J
Savoia, A
Auerbach, A D
Mathew, C G
Callen, D F
Cornelisse, C J
author_facet Cleton-Jansen, A-M
Moerland, E W
Pronk, J C
van Berkel, C G M
Apostolou, S
Crawford, J
Savoia, A
Auerbach, A D
Mathew, C G
Callen, D F
Cornelisse, C J
author_sort Cleton-Jansen, A-M
collection PubMed
description The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified. © 1999 Cancer Research Campaign
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spelling pubmed-23622532009-09-10 Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3 Cleton-Jansen, A-M Moerland, E W Pronk, J C van Berkel, C G M Apostolou, S Crawford, J Savoia, A Auerbach, A D Mathew, C G Callen, D F Cornelisse, C J Br J Cancer Regular Article The recently identified Fanconi anaemia A (FAA) gene is located on chromosomal band 16q24.3 within a region that has been frequently reported to show loss of heterozygosity (LOH) in breast cancer. FAA mutation analysis of 19 breast tumours with specific LOH at 16q24.3 was performed. Single-stranded conformational polymorphism (SSCP) analysis on cDNA and genomic DNA, and Southern blotting failed to identify any tumour-specific mutations. Five polymorphisms were identified, but frequencies of occurrence did not deviate from those in a normal control population. Therefore, the FAA gene is not the gene targeted by LOH at 16q24.3 in breast cancer. Another tumour suppressor gene in this chromosomal region remains to be identified. © 1999 Cancer Research Campaign Nature Publishing Group 1999-03 /pmc/articles/PMC2362253/ /pubmed/10098735 http://dx.doi.org/10.1038/sj.bjc.6690168 Text en Copyright © 1999 Cancer Research Campaign https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Regular Article
Cleton-Jansen, A-M
Moerland, E W
Pronk, J C
van Berkel, C G M
Apostolou, S
Crawford, J
Savoia, A
Auerbach, A D
Mathew, C G
Callen, D F
Cornelisse, C J
Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title_full Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title_fullStr Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title_full_unstemmed Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title_short Mutation analysis of the Fanconi anaemia A gene in breast tumours with loss of heterozygosity at 16q24.3
title_sort mutation analysis of the fanconi anaemia a gene in breast tumours with loss of heterozygosity at 16q24.3
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362253/
https://www.ncbi.nlm.nih.gov/pubmed/10098735
http://dx.doi.org/10.1038/sj.bjc.6690168
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