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Loss of DNA mismatch repair facilitates reactivation of a reporter plasmid damaged by cisplatin

In addition to recognizing and repairing mismatched bases in DNA, the mismatch repair (MMR) system also detects cisplatin DNA adducts and loss of MMR results in resistance to cisplatin. A comparison was made of the ability of MMR-proficient and -deficient cells to remove cisplatin adducts from their...

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Detalles Bibliográficos
Autores principales:	Cenni, B, Kim, H-K, Bubley, G J, Aebi, S, Fink, D, Teicher, B A, Howell, S B, Christen, R D
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1999
Materias:	Regular Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362265/ https://www.ncbi.nlm.nih.gov/pubmed/10360646 http://dx.doi.org/10.1038/sj.bjc.6690412

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